CG167 is a PROTAC degrader, which degrade CypA via a PROTAC mechanism. In Huh7 cells with HCV replicon, CG167 was antiviral. At low concentrations (1 μM), it was more potent than TWH106, and its antiviral activity was related to CypA degradation, which was also VHL - dependent.
MedKoo Cat#: 128475
Name: CG167
CAS#: N/A
Chemical Formula: C65H79N13O11S
Exact Mass: 1249.5743
Molecular Weight: 1250.49
Elemental Analysis: C, 62.43; H, 6.37; N, 14.56; O, 14.07; S, 2.56
The following data is based on the product molecular weight 1,250.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
