RNK-05047 is a BRD4 inhibitor. RNK-05047 functions by binding to BRD4 and HSP90, facilitating BRD4 degradation via the ubiquitin-proteasome system, thereby downregulating oncogenes like MYC and BCL2. Preclinical studies indicate that RNK05047 accumulates in tumor tissues and selectively degrades BRD4 without affecting BRD2 or BRD3, suggesting a favorable safety profile.
MedKoo Cat#: 128453
Name: RNK-05047 free base
CAS#: 2503035-53-6 (free base)
Chemical Formula: C47H53ClN10O4S
Exact Mass: 888.3660
Molecular Weight: 889.52
Elemental Analysis: C, 63.46; H, 6.01; Cl, 3.99; N, 15.75; O, 7.19; S, 3.60
The following data is based on the product molecular weight 889.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
