MS9024 is a DNMT1 degrader. MS9024 potently and selectively degraded DNMT1 in multiple cancer cell lines in a concentration-, time-, and proteasome-dependent manner without altering DNMT1 transcription. Further mechanism-of-action studies suggest that the DNMT1 degradation induced by MS9024 was not mediated by lysosome or cullin RING E3 ligases but could potentially be mediated by HECT E3 ligases and/or UHRF1.
MedKoo Cat#: 128434
Name: MS9024
CAS#: N/A
Chemical Formula: C21H22N6O2S
Exact Mass: 422.1525
Molecular Weight: 422.51
Elemental Analysis: C, 59.70; H, 5.25; N, 19.89; O, 7.57; S, 7.59
The following data is based on the product molecular weight 422.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
