MS83 is a PROTAC that degrades BRD4 and BRD3, reducing the amount of protein in cells. MS83 was also found to display increased proliferative activity over previously established dBET1, a CRBN-recruiting PROTAC.
MedKoo Cat#: 130291
Name: MS83
CAS#: 2762181-19-9
Chemical Formula: C52H55ClN10O8S2
Exact Mass: 1046.3334
Molecular Weight: 1047.64
Elemental Analysis: C, 59.62; H, 5.29; Cl, 3.38; N, 13.37; O, 12.22; S, 6.12
The following data is based on the product molecular weight 1,047.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
