MedKoo Cat#: 466206 | Name: PD0183812

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD0183812 is a potent CDK inhibitor.

Chemical Structure

PD0183812
PD0183812
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466206

Name: PD0183812

CAS#: unknown

Chemical Formula: C28H35N5O2

Exact Mass: 473.2791

Molecular Weight: 473.62

Elemental Analysis: C, 71.01; H, 7.45; N, 14.79; O, 6.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PD0183812; PD 0183812; PD-0183812;
IUPAC/Chemical Name
8-(bicyclo[2.2.1]heptan-2-yl)-2-((4-(4-(3-hydroxypropyl)piperidin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChi Key
PETCVZZPKYJZAU-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H35N5O2/c34-15-1-2-19-11-13-32(14-12-19)24-8-6-23(7-9-24)30-28-29-18-22-5-10-26(35)33(27(22)31-28)25-17-20-3-4-21(25)16-20/h5-10,18-21,25,34H,1-4,11-17H2,(H,29,30,31)
SMILES Code
OCCCC1CCN(C2=CC=C(NC3=NC(N(C4CC5CCC4C5)C(C=C6)=O)=C6C=N3)C=C2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Park H, Yeom MS, Lee S. Loop flexibility and solvent dynamics as determinants for the selective inhibition of cyclin-dependent kinase 4: comparative molecular dynamics simulation studies of CDK2 and CDK4. Chembiochem. 2004 Dec 3;5(12):1662-72. doi: 10.1002/cbic.200400214. PMID: 15505811. 2: Fry DW, Bedford DC, Harvey PH, Fritsch A, Keller PR, Wu Z, Dobrusin E, Leopold WR, Fattaey A, Garrett MD. Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6. J Biol Chem. 2001 May 18;276(20):16617-23. doi: 10.1074/jbc.M008867200. Epub 2001 Feb 6. PMID: 11278443.