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MedKoo Cat#: 128430 | Name: M084

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M084 is a TRPC4/5 inhibitor.

Chemical Structure

M084
M084
CAS#51314-51-3 (free base)

Theoretical Analysis

MedKoo Cat#: 128430

Name: M084

CAS#: 51314-51-3 (free base)

Chemical Formula: C11H15N3

Exact Mass: 189.1266

Molecular Weight: 189.26

Elemental Analysis: C, 69.81; H, 7.99; N, 22.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1992047-63-8 (HCl) 51314-51-3 (free base)
Synonym
M084; M-084; M 084
IUPAC/Chemical Name
N-butyl-1H-benzo[d]imidazol-2-amine
InChi Key
OKKUCNXCFWODOE-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15N3/c1-2-3-8-12-11-13-9-6-4-5-7-10(9)14-11/h4-7H,2-3,8H2,1H3,(H2,12,13,14)
SMILES Code
CCCCNC1=NC2=CC=CC=C2N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 189.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem. 2017 Feb;426(1-2):101-109. doi: 10.1007/s11010-016-2884-x. Epub 2016 Nov 16. PMID: 27854075. 2: Yang LP, Jiang FJ, Wu GS, Deng K, Wen M, Zhou X, Hong X, Zhu MX, Luo HR. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice. PLoS One. 2015 Aug 28;10(8):e0136255. doi: 10.1371/journal.pone.0136255. PMID: 26317356; PMCID: PMC4552833. 3: Yang L, Pierce S, Gould TW, Craviso GL, Leblanc N. Ultrashort nanosecond electric pulses activate a conductance in bovine adrenal chromaffin cells that involves cation entry through TRPC and NALCN channels. Arch Biochem Biophys. 2022 Jul 15;723:109252. doi: 10.1016/j.abb.2022.109252. Epub 2022 Apr 15. PMID: 35436445. 4: Péret B, Desnos T, Jost R, Kanno S, Berkowitz O, Nussaume L. Root architecture responses: in search of phosphate. Plant Physiol. 2014 Dec;166(4):1713-23. doi: 10.1104/pp.114.244541. Epub 2014 Oct 23. PMID: 25341534; PMCID: PMC4256877. 5: Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakur DP, Zhu J, Deng Z, Hu X, Wu M, McManus OB, Li M, Hong X, Zhu MX, Luo HR. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015 Jul;172(14):3495-509. doi: 10.1111/bph.13140. Epub 2015 May 11. PMID: 25816897; PMCID: PMC4507155. 6: Carver CM, DeWitt HR, Stoja AP, Shapiro MS. Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury. Front Neurosci. 2021 Aug 19;15:681144. doi: 10.3389/fnins.2021.681144. PMID: 34489621; PMCID: PMC8416999. 7: Wan BY, Mann S, Assem ES, Marson CM. Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction. Inflamm Res. 2010 Mar;59 Suppl 2:S231-3. doi: 10.1007/s00011-009-0136-1. PMID: 20033256. 8: Raven JA, Beardall J. The ins and outs of CO2. J Exp Bot. 2016 Jan;67(1):1-13. doi: 10.1093/jxb/erv451. Epub 2015 Oct 14. PMID: 26466660; PMCID: PMC4682431. 9: Raven JA, Colmer TD. Life at the boundary: photosynthesis at the soil-fluid interface. A synthesis focusing on mosses. J Exp Bot. 2016 Mar;67(6):1613-23. doi: 10.1093/jxb/erw012. Epub 2016 Feb 2. Erratum in: J Exp Bot. 2017 Nov 2;68(18):5247. doi: 10.1093/jxb/erw308. PMID: 26842980. 10: Banerjee A, Pasea L, Chung SC, Direk K, Asselbergs FW, Grobbee DE, Kotecha D, Anker SD, Dyszynski T, Tyl B, Denaxas S, Lumbers RT, Hemingway H. A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential. Eur J Heart Fail. 2022 Mar;24(3):466-480. doi: 10.1002/ejhf.2417. Epub 2022 Jan 26. Erratum in: Eur J Heart Fail. 2022 Sep;24(9):1739. doi: 10.1002/ejhf.2544. PMID: 34969173; PMCID: PMC9305958.