MedKoo Cat#: 558171 | Name: Kazinol B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kazinol B is a natural isoprenylated flavan and stimulates the gene expression and secretion of adiponectin, which is associated with a low risk of types 1 and 2 diabetes mellitus.

Chemical Structure

Kazinol B
Kazinol B
CAS#99624-27-8

Theoretical Analysis

MedKoo Cat#: 558171

Name: Kazinol B

CAS#: 99624-27-8

Chemical Formula: C30H36O4

Exact Mass: 460.2600

Molecular Weight: 460.61

Elemental Analysis: C, 78.23; H, 7.88; O, 13.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Kazinol B;
IUPAC/Chemical Name
5-((S)-6-(1,1-Dimethyl-allyl)-7-hydroxy-1-benzopyran-2-yl)-3-((E)-3-methyl-but-2-enyl)-4-(3-methyl-but-2-enyl)-benzene-1,2-diol
InChi Key
GGWMAHDWGWYVDR-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H36O4/c1-8-30(6,7)24-15-20-11-14-27(34-28(20)17-25(24)31)23-16-26(32)29(33)22(13-10-19(4)5)21(23)12-9-18(2)3/h8-11,14,16-17,31-33H,1,12-13,15H2,2-7H3
SMILES Code
OC1=CC(C2=CC=C3C(O2)=CC(O)=C(C(C)(C)C=C)C3)=C(C/C=C(C)\C)C(C/C=C(C)\C)=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee H, Li H, Jeong JH, Noh M, Ryu JH. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. doi: 10.1016/j.fitote.2016.05.006. Epub 2016 May 17. PubMed PMID: 27223849. 2: Ryu JH, Ahn H, Jin Lee H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003 Jun;74(4):350-4. PubMed PMID: 12781805. 3: Wang JP, Tsao LT, Raung SL, Lin CN. The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils. Br J Pharmacol. 1998 Oct;125(3):517-25. PubMed PMID: 9806335; PubMed Central PMCID: PMC1565651. 4: Wang JP, Hsu MF, Ko HH, Lin CN. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):500-9. Epub 2004 Nov 19. PubMed PMID: 15558242. 5: Lin CN, Lu CM, Lin HC, Fang SC, Shieh BJ, Hsu MF, Wang JP, Ko FN, Teng CM. Novel antiplatelet constituents from formosan moraceous plants. J Nat Prod. 1996 Sep;59(9):834-8. PubMed PMID: 8864236. 6: Sohn HY, Son KH, Kwon CS, Kwon GS, Kang SS. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine. 2004 Nov;11(7-8):666-72. PubMed PMID: 15636183. 7: Chi YS, Jong HG, Son KH, Chang HW, Kang SS, Kim HP. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem Pharmacol. 2001 Nov 1;62(9):1185-91. PubMed PMID: 11705451. 8: Park JY, Yuk HJ, Ryu HW, Lim SH, Kim KS, Park KH, Ryu YB, Lee WS. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. J Enzyme Inhib Med Chem. 2017 Dec;32(1):504-515. doi: 10.1080/14756366.2016.1265519. PubMed PMID: 28112000.