W23-1006 is a ALKBH5 Inhibitor. W23-1006 covalently bonds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM, representing roughly 30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. Cellular experiments demonstrated that W23-1006 could efficiently enhance the m6A level on fibronectin 1 (FN1) mRNA, leading to strong suppression of TNBC cell proliferation and migration in vitro as well as tumor growth and metastasis in vivo. W23-1006 could be a potential therapeutic option for cancer, such as TNBC treatment.
MedKoo Cat#: 128423
Name: W23-1006
CAS#: N/A
Chemical Formula: C17H12BrN3O5
Exact Mass: 416.9960
Molecular Weight: 418.20
Elemental Analysis: C, 48.82; H, 2.89; Br, 19.11; N, 10.05; O, 19.13
The following data is based on the product molecular weight 418.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
