Synonym
SGX942; SGX942; SGX 942. SGX94; SGX-94; SGX 94; dusquetide; L-arginyl-L-isoleucyl-L-valyl-L-prolyl-L-alaninamide.
IUPAC/Chemical Name
(S)-1-(L-arginyl-L-isoleucyl-L-valyl)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide
InChi Key
ZUJBBVJXXYRPFS-DYKIIFRCSA-N
InChi Code
InChI=1S/C25H47N9O5/c1-6-14(4)19(33-21(36)16(26)9-7-11-30-25(28)29)23(38)32-18(13(2)3)24(39)34-12-8-10-17(34)22(37)31-15(5)20(27)35/h13-19H,6-12,26H2,1-5H3,(H2,27,35)(H,31,37)(H,32,38)(H,33,36)(H4,28,29,30)/t14-,15-,16-,17-,18-,19-/m0/s1
SMILES Code
C[C@@H](C(N)=O)NC([C@H]1N(C([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)CCC1)=O
Appearance
white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
This agent promotes monocyte and macrophage recruitment to, and accelerates healing in damaged and infected tissue; it suppresses inflammation through the regulation of the expression of multiple cytokines. This agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as other types of infection. p62, an intracellular adaptor protein that functions downstream of certain signaling receptors, plays a key role in the activation of the innate immune system
Preparing Stock Solutions
The following data is based on the
product
molecular weight
553.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kudrimoti M, Curtis A, Azawi S, Worden F, Katz S, Adkins D, Bonomi M, Elder J,
Sonis ST, Straube R, Donini O. Dusquetide: A novel innate defense regulator
demonstrating a significant and consistent reduction in the duration of oral
mucositis in preclinical data and a randomized, placebo-controlled phase 2a
clinical study. J Biotechnol. 2016 Oct 13;239:115-125. doi:
10.1016/j.jbiotec.2016.10.010. [Epub ahead of print] PubMed PMID: 27746305.
2: North JR, Takenaka S, Rozek A, Kielczewska A, Opal S, Morici LA, Finlay BB,
Schaber CJ, Straube R, Donini O. A novel approach for emerging and antibiotic
resistant infections: Innate defense regulators as an agnostic therapy. J
Biotechnol. 2016 May 20;226:24-34. doi: 10.1016/j.jbiotec.2016.03.032. PubMed
PMID: 27015977; PubMed Central PMCID: PMC4867239.
