Z-VAD | pan-caspase inhibitor | CAS#162852-62-2

MedKoo Cat#: 128422 | Name: Z-VAD

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-VAD is a competitive, irreversible pan-caspase inhibitor.

Chemical Structure

Z-VAD

CAS#162852-62-2

Theoretical Analysis

MedKoo Cat#: 128422

Name: Z-VAD

CAS#: 162852-62-2

Chemical Formula: C20H27N3O8

Exact Mass: 437.1798

Molecular Weight: 437.45

Elemental Analysis: C, 54.91; H, 6.22; N, 9.61; O, 29.26

Price and Availability

Size	Price	Availability
5mg	USD 450.00	2 Weeks
25mg	USD 950.00	2 Weeks
100mg	USD 1,650.00	2 Weeks

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Related CAS #

No Data

Synonym

Z-VAD; ZVAD; Z VAD

IUPAC/Chemical Name

((benzyloxy)carbonyl)-L-valyl-L-alanyl-L-aspartic acid

InChi Key

ZEQLKYSQIAZNOS-NOLJZWGESA-N

InChi Code

InChI=1S/C20H27N3O8/c1-11(2)16(23-20(30)31-10-13-7-5-4-6-8-13)18(27)21-12(3)17(26)22-14(19(28)29)9-15(24)25/h4-8,11-12,14,16H,9-10H2,1-3H3,(H,21,27)(H,22,26)(H,23,30)(H,24,25)(H,28,29)/t12-,14-,16-/m0/s1

SMILES Code

OC(C[C@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C(C)C)=O)C)=O)C(O)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 437.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: He M, Zhang G, Shen F, Li X. Effects of Z-VaD-Ala-Asp-Fluoromethyl Ketone (Z-VAD-FMK) and Acetyl-Asp-Glu-Val-Asp-Aldehyde(Ac-DEVD-CHO) on Inflammation and Mucus Secretion in Mice Exposed to Cigarette Smoke. Int J Chron Obstruct Pulmon Dis. 2023 Feb 5;18:69-78. doi: 10.2147/COPD.S385748. PMID: 36777242; PMCID: PMC9910210. 2: Van Noorden CJ. The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition. Acta Histochem. 2001 Jul;103(3):241-51. doi: 10.1078/0065-1281-00601. PMID: 11482370. 3: Sripetchwandee J, Kongkaew A, Kumfu S, Chunchai T, Chattipakorn N, Chattipakorn SC. Ferrostatin-1 and Z-VAD-FMK potentially attenuated Iron- mediated neurotoxicity and rescued cognitive function in Iron-overloaded rats. Life Sci. 2023 Jan 15;313:121269. doi: 10.1016/j.lfs.2022.121269. Epub 2022 Dec 7. PMID: 36493877. 4: Pagano N, Longobardi V, De Canditiis C, Zuchegna C, Romano A, Michal Andrzej K, Pero ME, Gasparrini B. Effect of caspase inhibitor Z-VAD-FMK on bovine sperm cryotolerance. Reprod Domest Anim. 2020 Apr;55(4):530-536. doi: 10.1111/rda.13648. Epub 2020 Feb 17. PMID: 31985871. 5: Needs SH, Bootman MD, Grotzke JE, Kramer HB, Allman SA. Off-target inhibition of NGLY1 by the polycaspase inhibitor Z-VAD-fmk induces cellular autophagy. FEBS J. 2022 Jun;289(11):3115-3131. doi: 10.1111/febs.16345. Epub 2022 Jan 18. PMID: 34995415; PMCID: PMC9304259. 6: Fransolet M, Noël L, Henry L, Labied S, Blacher S, Nisolle M, Munaut C. Evaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation. J Assist Reprod Genet. 2019 Feb;36(2):349-359. doi: 10.1007/s10815-018-1353-8. Epub 2018 Nov 3. PMID: 30390176; PMCID: PMC6420548. 7: Costa Pereira LM, Thongkittidilok C, Lopes MD, Songsasen N. Effect of anti- apoptotic drug Z-VAD-FMK on in vitro viability of dog follicles. Theriogenology. 2018 Dec;122:124-129. doi: 10.1016/j.theriogenology.2018.09.012. Epub 2018 Sep 15. PMID: 30248613. 8: Chang H, Sun F, Tian K, Wang W, Zhou K, Zha D, Qiu J. Caspase inhibitor z-VAD-FMK increases the survival of hair cells after Actinomycin-D-induced damage in vitro. Neurosci Lett. 2020 Jul 27;732:135089. doi: 10.1016/j.neulet.2020.135089. Epub 2020 May 25. PMID: 32464263. 9: Yu C, Lei Z, Li X, Huang LH, Li ZQ, Zhu HW, Han D, Huang H, Yu X. Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis. Biochem Genet. 2022 Apr;60(2):598-610. doi: 10.1007/s10528-021-10107-1. Epub 2021 Jul 29. Erratum in: Biochem Genet. 2022 Apr;60(2):842. doi: 10.1007/s10528-021-10132-0. PMID: 34327615. 10: Niu Y, Dai J, Chen Y, Wu C, Zhang S, Zhang D. Positive effect of apoptotic inhibitor z-vad-fmk on vitrified-thawed porcine mii stage oocytes. Cryo Letters. 2016 May-Jun;37(3):188-95. PMID: 27393955.