K114 | CAS#872201-12-2 | XBP1 mRNA splicing inhibitor

MedKoo Cat#: 463424 | Name: K114

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K114 is an inhibitor of ER stress-induced splicing of XBP1 mRNA as well as reporter luciferase expression in HCT116 cells derived from human colorectal carcinoma, and inhibiting ribonuclease activity of human IRE1α in vitro.

Chemical Structure

K114

CAS#872201-12-2

Theoretical Analysis

MedKoo Cat#: 463424

Name: K114

CAS#: 872201-12-2

Chemical Formula: C22H17BrO2

Exact Mass: 392.0412

Molecular Weight: 393.28

Elemental Analysis: C, 67.19; H, 4.36; Br, 20.32; O, 8.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

K114; K 114; K-114;

IUPAC/Chemical Name

4,4'-((1E,1'E)-(2-bromo-1,4-phenylene)bis(ethene-2,1-diyl))diphenol

InChi Key

OXPHQQMZTXMEGO-RJTULKDBSA-N

InChi Code

InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+

SMILES Code

OC(C=C1)=CC=C1/C=C/C2=CC=C(/C=C/C3=CC=C(O)C=C3)C(Br)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 393.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jin B, Ishikawa T, Taniguchi M, Ninagawa S, Okada T, Kagaya S, Mori K. Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish. Cell Struct Funct. 2020 Feb 7;45(1):23-31. doi: 10.1247/csf.19032. Epub 2019 Dec 26. PMID: 31875595. 2: Liu J, Ye YH, Shao YH, Tu ZC. Observation of the structural changes of α-lactalbumin induced by ultrasonic prior to glycated modification. J Food Biochem. 2019 Nov;43(11):e13017. doi: 10.1111/jfbc.13017. Epub 2019 Sep 8. PMID: 31495937. 3: Maslovskaja J, Saare M, Liiv I, Rebane A, Peterson P. Extended HSR/CARD domain mediates AIRE binding to DNA. Biochem Biophys Res Commun. 2015 Dec 25;468(4):913-20. doi: 10.1016/j.bbrc.2015.11.056. Epub 2015 Nov 27. PMID: 26607109.