IUPAC/Chemical Name
ethyl 5-(3-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamido)thiophene-2-carboxylate
InChi Key
SPZMRFVNCRFNBJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22N2O5S2/c1-2-30-23(27)20-12-13-21(31-20)24-22(26)17-8-5-10-18(15-17)32(28,29)25-14-6-9-16-7-3-4-11-19(16)25/h3-5,7-8,10-13,15H,2,6,9,14H2,1H3,(H,24,26)
SMILES Code
O=S(N1C2=C(C=CC=C2)CCC1)(C3=CC(C(NC4=CC=C(C(OCC)=O)S4)=O)=CC=C3)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
470.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wu M, Xie Y, Cui X, Huang C, Zhang R, He Y, Li X, Liu M, Cen S, Zhou J.
Rational drug design for androgen receptor and glucocorticoids receptor dual
antagonist. Eur J Med Chem. 2019 Mar 15;166:232-242. doi:
10.1016/j.ejmech.2019.01.036. Epub 2019 Jan 26. PMID: 30711833.
2: Li C, Han X, Yan Q, Ji Y, Zhang R, Yuan D, Yang F, Wang J, Wu M, Zhou J.
Design and Synthesis of Dual-Target Inhibitors Targeting Androgen Receptors and
Glucocorticoid Receptors to Overcome Antiandrogen Resistance in Castration-
Resistant Prostate Cancer. J Med Chem. 2024 Feb 22. doi:
10.1021/acs.jmedchem.3c01668. Epub ahead of print. PMID: 38385428.
