JC744 is a chemical probe and is responsible for stabilizing p53-Y220C in-vitro (Kd = 320 nM). P53 is a tumor suppressor that often becomes inactivated in human cancers, with Y220C being the most prevalent p53 mutant. Destabilization caused by the mutation, a result of a pocket at the surface of the DNA-binding domain, leads to rapid aggregation and denaturation.
MedKoo Cat#: 130133
Name: JC744
CAS#: N/A
Chemical Formula: C16H15FIN3O3S
Exact Mass: 474.9863
Molecular Weight: 475.28
Elemental Analysis: C, 40.43; H, 3.18; F, 4.00; I, 26.70; N, 8.84; O, 10.10; S, 6.75
The following data is based on the product molecular weight 475.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
