MedKoo Cat#: 463825 | Name: F0045

Description:

WARNING: This product is for research use only, not for human or veterinary use.

F0045 is a novel influenza A hemagglutinin (HA) fusion inhibitor, preventing HA from transitioning to the post-fusion state at pH 5.0.

Chemical Structure

F0045
F0045
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463825

Name: F0045

CAS#: unknown

Chemical Formula: C17H15Cl2NO2

Exact Mass: 335.0480

Molecular Weight: 336.21

Elemental Analysis: C, 60.73; H, 4.50; Cl, 21.09; N, 4.17; O, 9.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
F0045; F 0045; F-0045;
IUPAC/Chemical Name
(R)-(2,4-dichlorophenyl)(2-phenylmorpholino)methanone
InChi Key
GMCUGOLAHOHCSS-INIZCTEOSA-N
InChi Code
InChI=1S/C17H15Cl2NO2/c18-13-6-7-14(15(19)10-13)17(21)20-8-9-22-16(11-20)12-4-2-1-3-5-12/h1-7,10,16H,8-9,11H2/t16-/m0/s1
SMILES Code
O=C(C1=CC=C(Cl)C=C1Cl)N2C[C@@H](C3=CC=CC=C3)OCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yao Y, Kadam RU, Lee CD, Woehl JL, Wu NC, Zhu X, Kitamura S, Wilson IA, Wolan DW. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18431-18438. doi: 10.1073/pnas.2006893117. Epub 2020 Jul 20. PMID: 32690700; PMCID: PMC7414093.