Emoquine‑1 is a malaria agent. Emoquine‑1 showed efficient against multidrug-resistant plasmodium parasites, including the artemisinin-resistant Quiescent Stage, and Also Active In Vivo. Emoquine-1 was the most active on proliferative P. falciparum, with IC50 values in the range of 20−55 nM and a high selectivity index with respect to mammalian cells. This drug retained its activity on several multiresistant field isolates from Cambodia and Guiana, exhibited no cross-resistance to artemisinin, and is also very active against the quiescent stage of the artemisinin-resistant parasites, three features that constitute the gold standard for new antimalarial drugs. In vivo, emoquine-1 is active against Plasmodium vinckei petteri.
MedKoo Cat#: 128381
Name: Emoquine‑1
CAS#: N/A
Chemical Formula: C30H28ClN3O6
Exact Mass: 561.1667
Molecular Weight: 562.02
Elemental Analysis: C, 64.11; H, 5.02; Cl, 6.31; N, 7.48; O, 17.08
The following data is based on the product molecular weight 562.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
