| CAS# 679-90-3 | xxxx

MedKoo Cat#: 581121 | Name: Roflurane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Roflurane is a halocarbon drug which was investigated as an inhalational anesthetic.

Chemical Structure

Roflurane

CAS#679-90-3

Theoretical Analysis

MedKoo Cat#: 581121

Name: Roflurane

CAS#: 679-90-3

Chemical Formula: C6H6Br2F6O

Exact Mass: 365.8690

Molecular Weight: 367.91

Elemental Analysis: C, 19.59; H, 1.64; Br, 43.44; F, 30.98; O, 4.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Roflurane; oflurano; Rofluran; Rofluranum; DA 893; DA-893;

IUPAC/Chemical Name

(2-Brom-1,1,2-trifluoroethyl)-methylether

InChi Key

InChi Code

InChI=1S/C6H6Br2F6O/c7-3(9)5(11,12)1-15-2-6(13,14)4(8)10/h3-4H,1-2H2

SMILES Code

UGISDZKPLWRDPV-UHFFFAOYSA-N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 367.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen Q, Kinde MN, Arjunan P, Wells MM, Cohen AE, Xu Y, Tang P. Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC. Sci Rep. 2015 Sep 8;5:13833. doi: 10.1038/srep13833. PubMed PMID: 26346220; PubMed Central PMCID: PMC4561908. 2: Gianotti G, Valverde A, Johnson R, Sinclair M, Gibson T, Dyson DH. Influence of prior determination of baseline minimum alveolar concentration (MAC) of isoflurane on the effect of ketamine on MAC in dogs. Can J Vet Res. 2014 Jul;78(3):207-13. PubMed PMID: 24982552; PubMed Central PMCID: PMC4068412. 3: Truchetti G, Burns P, Nichols S, Parent J. Effects of isoflurane on somatosensory-evoked potentials in calves: a pilot study. Can J Vet Res. 2015 Jan;79(1):22-30. PubMed PMID: 25673905; PubMed Central PMCID: PMC4283230. 4: Liu R, Li Y, Liu J, Zhang WS, Yi XQ, Xu J. Effects of intravenous bolus injection of emulsified isoflurane on QTc interval of healthy volunteers in Pharmacokinetics study. Pak J Pharm Sci. 2014 Sep;27(5):1183-9. PubMed PMID: 25176376. 5: Fan HG, Jiang S, Lin DQ, Lu DZ, Li L, Ji W, Li WZ. Comparison of anaesthetic and analgesic effects of emulsified isoflurane used alone or combined with lidocaine and fentanyl in dogs. N Z Vet J. 2014 May;62(3):123-9. doi: 10.1080/00480169.2013.859976. Epub 2013 Dec 17. PubMed PMID: 24341657. 6: Shan J, Sun L, Wang D, Li X. Comparison of the neuroprotective effects and recovery profiles of isoflurane, sevoflurane and desflurane as neurosurgical pre-conditioning on ischemia/reperfusion cerebral injury. Int J Clin Exp Pathol. 2015 Feb 1;8(2):2001-9. eCollection 2015. PubMed PMID: 25973096; PubMed Central PMCID: PMC4396329. 7: Gardhouse SM, Eshar D, Bello N, Mason D. Venous blood gas analytes during isoflurane anesthesia in black-tailed prairie dogs (Cynomys ludovicianus). J Am Vet Med Assoc. 2015 Aug 15;247(4):404-8. doi: 10.2460/javma.247.4.404. PubMed PMID: 26225612. 8: Yang XL, Zhang WS, Liu J, Yang ZB, Jiang XH. Pharmacokinetics of intravenous emulsified isoflurane in beagle dogs. Br J Anaesth. 2013 Jan;110(1):128-36. doi: 10.1093/bja/aes311. Epub 2012 Sep 25. PubMed PMID: 23015620. 9: Berry SH, Panciera DL. The effect of experimentally induced hypothyroidism on the isoflurane minimum alveolar concentration in dogs. Vet Anaesth Analg. 2015 Jan;42(1):50-4. doi: 10.1111/vaa.12156. Epub 2014 Mar 14. PubMed PMID: 24628964. 10: Polese G, Winlow W, Di Cosmo A. Dose-dependent effects of the clinical anesthetic isoflurane on Octopus vulgaris: a contribution to cephalopod welfare. J Aquat Anim Health. 2014 Dec;26(4):285-94. doi: 10.1080/08997659.2014.945047. PubMed PMID: 25369208. 11: Tao G, Xue Q, Luo Y, Li G, Xia Y, Yu B. Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the Akt/GSK3β Signaling Pathway. Biomed Res Int. 2016;2016:7919640. doi: 10.1155/2016/7919640. Epub 2016 Feb 1. PubMed PMID: 27057548; PubMed Central PMCID: PMC4753322. 12: Dabir S, Mohammad-Taheri Z, Parsa T, Abbasi-Nazari M, Radpay B, Radmand G. Effects of propofol versus isoflurane on liver function after open thoracotomy. Asian Cardiovasc Thorac Ann. 2015 Mar;23(3):292-8. doi: 10.1177/0218492314551972. Epub 2014 Sep 15. PubMed PMID: 25227774. 13: Barletta M, Quandt J, Hofmeister E. Determination of minimum alveolar concentration of isoflurane in dogs and cats using the up-and-down method. A preliminary study. Res Vet Sci. 2016 Jun;106:81-3. doi: 10.1016/j.rvsc.2016.03.011. Epub 2016 Mar 18. PubMed PMID: 27234540. 14: Botman J, Dugdale A, Gabriel F, Vandeweerd JM. Cardiorespiratory parameters in the awake pigeon and during anaesthesia with isoflurane. Vet Anaesth Analg. 2016 Jan;43(1):63-71. doi: 10.1111/vaa.12262. Epub 2015 Apr 30. PubMed PMID: 25929705. 15: Kim JK, Kim DK, Lee MJ. Relationship of bispectral index to minimum alveolar concentration during isoflurane, sevoflurane or desflurane anaesthesia. J Int Med Res. 2014 Feb;42(1):130-7. doi: 10.1177/0300060513505525. Epub 2013 Dec 23. PubMed PMID: 24366495. 16: Miller AL, Golledge HD, Leach MC. The Influence of Isoflurane Anaesthesia on the Rat Grimace Scale. PLoS One. 2016 Nov 17;11(11):e0166652. doi: 10.1371/journal.pone.0166652. eCollection 2016. PubMed PMID: 27855184; PubMed Central PMCID: PMC5114010. 17: Li CX, Patel S, Auerbach EJ, Zhang X. Dose-dependent effect of isoflurane on regional cerebral blood flow in anesthetized macaque monkeys. Neurosci Lett. 2013 Apr 29;541:58-62. doi: 10.1016/j.neulet.2013.02.007. Epub 2013 Feb 18. PubMed PMID: 23428509; PubMed Central PMCID: PMC4349366. 18: Barletta M, Kleine SA, Hofmeister EH, Thoresen M, Peroni JF, Knych HK, Scharf AM, Quandt JE. Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. Am J Vet Res. 2016 Feb;77(2):119-26. doi: 10.2460/ajvr.77.2.119. PubMed PMID: 27027704. 19: Zhang B, Tian M, Zhen Y, Yue Y, Sherman J, Zheng H, Li S, Tanzi RE, Marcantonio ER, Xie Z. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg. 2012 Feb;114(2):410-5. doi: 10.1213/ANE.0b013e31823b2602. Epub 2011 Nov 10. PubMed PMID: 22075020; PubMed Central PMCID: PMC3972614. 20: Zhou C, Liu J. A novel intravenous general anesthetic--emulsified isoflurane: from bench to bedside. Front Med. 2012 Dec;6(4):381-7. doi: 10.1007/s11684-012-0229-z. Epub 2012 Dec 7. Review. PubMed PMID: 23224415.