| MedKoCatestatin | inhibitor of norepinephrine release | CAS#142211-96-9

MedKoo Cat#: 128349 | Name: Catestatin (bovine)

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Catestatin is a peptide derivative of chromogranin A and an inhibitor of norepinephrine release.

Chemical Structure

Catestatin (bovine)

CAS#142211-96-9

Theoretical Analysis

MedKoo Cat#: 128349

Name: Catestatin (bovine)

CAS#: 142211-96-9

Chemical Formula: C107H173N37O26S

Exact Mass: 2424.3073

Molecular Weight: 2425.85

Elemental Analysis: C, 52.98; H, 7.19; N, 21.36; O, 17.15; S, 1.32

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks
25mg	USD 1,050.00	2 Weeks

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Synonym

Catestatin (bovine); bCgA344-364; Bovine Chromogranin A344-364

IUPAC/Chemical Name

L-arginyl-L-seryl-L-methionyl-L-arginyl-L-leucyl-L-seryl-L-phenylalanyl-L-arginyl-L-alanyl-L-arginylglycyl-L-tyrosylglycyl-L-phenylalanyl-L-arginylglycyl-L-prolylglycyl-L-leucyl-L-glutaminyl-L-leucine

InChi Key

HCEYIDADOJWYIM-DIWOTYQXSA-N

InChi Code

InChI=1S/C107H173N37O26S/c1-57(2)45-72(95(162)137-70(35-36-81(109)148)93(160)141-77(102(169)170)47-59(5)6)130-84(151)53-127-101(168)80-30-20-43-144(80)85(152)54-128-89(156)67(27-17-40-122-105(114)115)134-97(164)75(48-61-21-11-9-12-22-61)132-83(150)52-126-90(157)74(50-63-31-33-64(147)34-32-63)131-82(149)51-125-88(155)66(26-16-39-121-104(112)113)133-86(153)60(7)129-91(158)68(28-18-41-123-106(116)117)136-98(165)76(49-62-23-13-10-14-24-62)140-100(167)79(56-146)143-96(163)73(46-58(3)4)139-92(159)69(29-19-42-124-107(118)119)135-94(161)71(37-44-171-8)138-99(166)78(55-145)142-87(154)65(108)25-15-38-120-103(110)111/h9-14,21-24,31-34,57-60,65-80,145-147H,15-20,25-30,35-56,108H2,1-8H3,(H2,109,148)(H,125,155)(H,126,157)(H,127,168)(H,128,156)(H,129,158)(H,130,151)(H,131,149)(H,132,150)(H,133,153)(H,134,164)(H,135,161)(H,136,165)(H,137,162)(H,138,166)(H,139,159)(H,140,167)(H,141,160)(H,142,154)(H,143,163)(H,169,170)(H4,110,111,120)(H4,112,113,121)(H4,114,115,122)(H4,116,117,123)(H4,118,119,124)/t60-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-/m0/s1

SMILES Code

O=C(N[C@@H](CO[H])C(N[C@@H](CCSC)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N[C@@H](CC1=CC=C(O[H])C=C1)C(NCC(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@@H](CCC(N[H])=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=CC=C4)=O)=O)CC(C)C)=O)=O)=O)[C@H](CCC/N=C(N[H])/N)N[H]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,425.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zalewska E, Kmieć P, Sworczak K. Role of Catestatin in the Cardiovascular System and Metabolic Disorders. Front Cardiovasc Med. 2022 May 19;9:909480. doi: 10.3389/fcvm.2022.909480. PMID: 35665253; PMCID: PMC9160393. 2: Jati S, Mahata S, Das S, Chatterjee S, Mahata SK. Catestatin: Antimicrobial Functions and Potential Therapeutics. Pharmaceutics. 2023 May 20;15(5):1550. doi: 10.3390/pharmaceutics15051550. PMID: 37242791; PMCID: PMC10220906. 3: Qiu Z, Fan Y, Wang Z, Huang F, Li Z, Sun Z, Hua S, Jin W, Chen Y. Catestatin Protects Against Diastolic Dysfunction by Attenuating Mitochondrial Reactive Oxygen Species Generation. J Am Heart Assoc. 2023 May 2;12(9):e029470. doi: 10.1161/JAHA.123.029470. Epub 2023 Apr 29. PMID: 37119063; PMCID: PMC10227223. 4: Bralewska M, Pietrucha T, Sakowicz A. The Role of Catestatin in Preeclampsia. Int J Mol Sci. 2024 Feb 20;25(5):2461. doi: 10.3390/ijms25052461. PMID: 38473713; PMCID: PMC10931722. 5: Muntjewerff EM, Christoffersson G, Mahata SK, van den Bogaart G. Putative regulation of macrophage-mediated inflammation by catestatin. Trends Immunol. 2022 Jan;43(1):41-50. doi: 10.1016/j.it.2021.11.002. Epub 2021 Nov 27. PMID: 34844850; PMCID: PMC10843896. 6: Muntjewerff EM, Dunkel G, Nicolasen MJT, Mahata SK, van den Bogaart G. Catestatin as a Target for Treatment of Inflammatory Diseases. Front Immunol. 2018 Oct 4;9:2199. doi: 10.3389/fimmu.2018.02199. PMID: 30337922; PMCID: PMC6180191. 7: Mahata SK, Kiranmayi M, Mahapatra NR. Catestatin: A Master Regulator of Cardiovascular Functions. Curr Med Chem. 2018;25(11):1352-1374. doi: 10.2174/0929867324666170425100416. PMID: 28443506. 8: Zhao Y, Zhu D. Potential applications of catestatin in cardiovascular diseases. Biomark Med. 2016 Aug;10(8):877-88. doi: 10.2217/bmm-2016-0086. Epub 2016 Jul 14. PMID: 27415768. 9: Wu Z, Zhu D. The important role of catestatin in cardiac remodeling. Biomarkers. 2014 Dec;19(8):625-30. doi: 10.3109/1354750X.2014.950331. Epub 2014 Aug 19. PMID: 25136978. 10: Tüten N, Güralp O, Gök K, Hamzaoglu K, Oner YO, Makul M, Bulut H, Irmak K, Tüten A, Malik E. Serum catestatin level is increased in women with preeclampsia. J Obstet Gynaecol. 2022 Jan;42(1):55-60. doi: 10.1080/01443615.2021.1873922. Epub 2021 May 3. PMID: 33938370.