U 78608 | CAS#123444-35-9 | antibiotic

MedKoo Cat#: 585353 | Name: U 78608

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 78608 is an iron-chelating monocarbam antibiotic.

Chemical Structure

U 78608

CAS#123444-35-9

Theoretical Analysis

MedKoo Cat#: 585353

Name: U 78608

CAS#: 123444-35-9

Chemical Formula: C21H22N10O11S2

Exact Mass: 654.0911

Molecular Weight: 654.59

Elemental Analysis: C, 38.53; H, 3.39; N, 21.40; O, 26.89; S, 9.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

U 78608; U78608; U-78608

IUPAC/Chemical Name

2-[(E)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(3S)-1-[[3-(5-hydroxy-4-oxo-1H-pyridin-2-yl)-4-methyl-5-oxo-1,2,4-triazol-1-yl]sulfonylcarbamoyl]-2-oxoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid

InChi Key

ACNHWHSFERZOFC-YDWAADTNSA-N

InChi Code

InChI=1S/C21H22N10O11S2/c1-21(2,17(36)37)42-27-13(10-7-43-18(22)25-10)15(34)24-9-6-30(16(9)35)19(38)28-44(40,41)31-20(39)29(3)14(26-31)8-4-11(32)12(33)5-23-8/h4-5,7,9,33H,6H2,1-3H3,(H2,22,25)(H,23,32)(H,24,34)(H,28,38)(H,36,37)/b27-13+/t9-/m0/s1

SMILES Code

CC(C)(O/N=C(C1=CSC(N)=N1)/C(N[C@@H]2C(N(C(NS(=O)(N3N=C(C4=CC(C(O)=CN4)=O)N(C)C3=O)=O)=O)C2)=O)=O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 654.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barbachyn MR, Tuominen TC. Synthesis and structure-activity relationships of monocarbams leading to U-78608. J Antibiot (Tokyo). 1990 Sep;43(9):1199-203. PubMed PMID: 2211385. 2: Zurenko GE, Truesdell SE, Yagi BH, Mourey RJ, Laborde AL. In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608. Antimicrob Agents Chemother. 1990 May;34(5):884-8. PubMed PMID: 2193625; PubMed Central PMCID: PMC171711. 3: Dalga RJ, Lambert WJ. Development of a polymer-based reversed-phase high-performance liquid chromatographic stability indicating assay for U-78 608, an iron complexing monocarbam antibiotic. J Chromatogr. 1989 Aug 30;477(2):427-33. PubMed PMID: 2624661.