2-OHE1 | CAS#362-06-1 | MCF-7 proliferation inhibitor

MedKoo Cat#: 464822 | Name: 2-OHE1

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-hydroxy Estrone (2-OHE1) is an active metabolite of the endogenous estrogen estrone. It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1A2, CYP1A1, and CYP1B1 and metabolized to 2-methoxy estrone by catechol-O-methyltransferase (COMT). 2-hydroxy Estrone (10 µM) inhibits the proliferation of estrogen receptor-positive MCF-7, but not estrogen receptor-negative MDA-MB-231, breast cancer cells cultured with the COMT inhibitor quinalizarin. It inhibits iron-ADP-adriamycin complex-induced lipid peroxidation of liposomes prepared from rat liver microsomes (IC50 = 2.7 µM).

Chemical Structure

2-OHE1

CAS#362-06-1

Theoretical Analysis

MedKoo Cat#: 464822

Name: 2-OHE1

CAS#: 362-06-1

Chemical Formula: C18H22O3

Exact Mass: 286.1569

Molecular Weight: 286.37

Elemental Analysis: C, 75.50; H, 7.74; O, 16.76

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks
5mg	USD 1,350.00	2 Weeks

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Related CAS #

No Data

Synonym

2-OHE1; 2OHE1; 2 OHE1; 2-hydroxy Estrone; 2 hydroxy Estrone; Catecholestrone; 2-hydroxy E1; 2 hydroxy E1; 2-Hydroxyesterone

IUPAC/Chemical Name

(8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one

InChi Key

SWINWPBPEKHUOD-JPVZDGGYSA-N

InChi Code

InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1

SMILES Code

C[C@]12[C@]([H])([C@]3([C@@]([H])(C4=CC(O)=C(C=C4CC3)O)CC2)[H])CCC1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	104.76
	DMSO	30.0	104.76
	Ethanol	30.0	104.76
	Ethanol:PBS (pH 7.2) (1:2)	0.3	1.15

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 286.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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