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MedKoo Cat#: 145675 | Name: KR-31173

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KR-31173 is a radioligand. KR31173 has been introduced for PET imaging of the angiotensin II subtype 1 receptor (AT1R).

Chemical Structure

KR-31173
KR-31173
CAS#260554-07-2

Theoretical Analysis

MedKoo Cat#: 145675

Name: KR-31173

CAS#: 260554-07-2

Chemical Formula: C31H30N8O2

Exact Mass: 546.2500

Molecular Weight: 546.64

Elemental Analysis: C, 68.12; H, 5.53; N, 20.50; O, 5.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KR-31173; KR31173; KR 31173;
IUPAC/Chemical Name
2-(3-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-(methoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl)pyridine 1-oxide
InChi Key
KTIHPEHEYAUWHK-UHFFFAOYSA-N
InChi Code
1S/C31H30N8O2/c1-3-4-12-29-32-26-18-25(28-11-7-8-17-39(28)40)27(20-41-2)33-31(26)38(29)19-21-13-15-22(16-14-21)23-9-5-6-10-24(23)30-34-36-37-35-30/h5-11,13-18H,3-4,12,19-20H2,1-2H3,(H,34,35,36,37)
SMILES Code
CCCCC1=NC2=C(N=C(COC)C(=C2)C3=CC=CC=[N+]3[O-])N1CC4=CC=C(C=C4)C5=C(C=CC=C5)C6=NN=NN6
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 546.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leung K. 2-Butyl-5-[11C]methoxymethyl-6-(1-oxopyridin-2-yl)-3-[[2' -(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine . 2006 May 12 [updated 2012 Mar 21]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641686. 2: Valenta I, Pacher P, Dilsizian V, Schindler TH. Novel Myocardial PET/CT Receptor Imaging and Potential Therapeutic Targets. Curr Cardiol Rep. 2019 May 18;21(7):55. doi: 10.1007/s11886-019-1148-2. PMID: 31104205. 3: Zober TG, Mathews WB, Seckin E, Yoo SE, Hilton J, Xia J, Sandberg K, Ravert HT, Dannals RF, Szabo Z. PET Imaging of the AT1 receptor with [11C]KR31173. Nucl Med Biol. 2006 Jan;33(1):5-13. doi: 10.1016/j.nucmedbio.2005.08.005. PMID: 16459253; PMCID: PMC1819586. 4: Gulaldi NC, Xia J, Feng T, Hong K, Mathews WB, Ruben D, Kamel IR, Tsui BM, Szabo Z. Modeling of the renal kinetics of the AT1 receptor specific PET radioligand [11C]KR31173. Biomed Res Int. 2013;2013:835859. doi: 10.1155/2013/835859. Epub 2013 Sep 8. PMID: 24083243; PMCID: PMC3780470. 5: Fukushima K, Bravo PE, Higuchi T, Schuleri KH, Lin X, Abraham MR, Xia J, Mathews WB, Dannals RF, Lardo AC, Szabo Z, Bengel FM. Molecular hybrid positron emission tomography/computed tomography imaging of cardiac angiotensin II type 1 receptors. J Am Coll Cardiol. 2012 Dec 18;60(24):2527-34. doi: 10.1016/j.jacc.2012.09.023. Epub 2012 Nov 14. PMID: 23158533; PMCID: PMC3522758. 6: Xia J, Seckin E, Xiang Y, Vranesic M, Mathews WB, Hong K, Bluemke DA, Lerman LO, Szabo Z. Positron-emission tomography imaging of the angiotensin II subtype 1 receptor in swine renal artery stenosis. Hypertension. 2008 Feb;51(2):466-73. doi: 10.1161/HYPERTENSIONAHA.107.102715. Epub 2008 Jan 2. PMID: 18172054. 7: Feng T, Tsui BM, Li X, Vranesic M, Lodge MA, Gulaldi NC, Szabo Z. Image- derived and arterial blood sampled input functions for quantitative PET imaging of the angiotensin II subtype 1 receptor in the kidney. Med Phys. 2015 Nov;42(11):6736-44. doi: 10.1118/1.4934375. PMID: 26520763; PMCID: PMC4627933. 8: Higuchi T, Fukushima K, Xia J, Mathews WB, Lautamäki R, Bravo PE, Javadi MS, Dannals RF, Szabo Z, Bengel FM. Radionuclide imaging of angiotensin II type 1 receptor upregulation after myocardial ischemia-reperfusion injury. J Nucl Med. 2010 Dec;51(12):1956-61. doi: 10.2967/jnumed.110.079855. Epub 2010 Nov 15. PMID: 21078800. 9: Mathews WB, Yoo SE, Lee SH, Scheffel U, Rauseo PA, Zober TG, Gocco G, Sandberg K, Ravert HT, Dannals RF, Szabo Z. A novel radioligand for imaging the AT1 angiotensin receptor with PET. Nucl Med Biol. 2004 Jul;31(5):571-4. doi: 10.1016/j.nucmedbio.2003.10.014. PMID: 15219274.

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