JQ1-TCO is a clickable BET inhibitor for use as a chemical probe in targeted cancer therapeutics, as well as a method of degrading BRD4. JQT-TCO, which was derived from the BET inhibitor JQ1, was found to lead to a reduction in proliferation, and very similar gene expressions to JQ1. JQ1-TCO was vital in demonstrating the importance of increasing bone marrow penetration in order to increase the efficacy of BET inhibitors.
MedKoo Cat#: 130138
Name: JQ1-TCO
CAS#: N/A
Chemical Formula: C31H37ClN6O3S
Exact Mass: 608.2336
Molecular Weight: 609.19
Elemental Analysis: C, 61.12; H, 6.12; Cl, 5.82; N, 13.80; O, 7.88; S, 5.26
The following data is based on the product molecular weight 609.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
