Related CAS #
936802-94-7 (tautomer)
936737-04-1 (tautomer sodium)
25020-14-8
Synonym
Fructose-arginine; Fructose-arginine; Fructose arginine; Arginyl-fructose; Arginyl fructose; J1.147.777A;
IUPAC/Chemical Name
((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)arginine
InChi Key
UEZWWYVAHKTISC-JPMHVPNBSA-N
InChi Code
InChI=1S/C12H24N4O7/c13-12(14)15-3-1-2-6(11(22)23)16-4-7(18)9(20)10(21)8(19)5-17/h6,8-10,16-17,19-21H,1-5H2,(H,22,23)(H4,13,14,15)/t6?,8-,9-,10-/m1/s1
SMILES Code
O[C@H](C(CNC(C(O)=O)CCCNC(N)=N)=O)[C@@H]([C@@H](CO)O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Korean Red Ginseng extract (RGE) has been reported to act as an inflammasome modulator. Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
336.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Student J, Sowers J, Lockette W. THIRSTY FOR FRUCTOSE: Arginine Vasopressin, Fructose, and the Pathogenesis of Metabolic and Renal Disease. Front Cardiovasc Med. 2022 May 17;9:883365. doi: 10.3389/fcvm.2022.883365. PMID: 35656391; PMCID: PMC9152091.
2: Ahn H, Han BC, Lee SH, Lee GS. Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation. J Ginseng Res. 2020 Nov;44(6):808-814. doi: 10.1016/j.jgr.2020.06.002. Epub 2020 Jul 21. PMID: 33192124; PMCID: PMC7655492.
3: Motta NAV, Fumian MM, Medeiros RF, Lima GF, Scaramello CBV, Oliveira KJ, Nóbrega ACL, Brito FCF. Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome. Int J Endocrinol. 2019 Jan 6;2019:8919435. doi: 10.1155/2019/8919435. PMID: 30723500; PMCID: PMC6339713.
4: Medeiros RF, Gaique TG, Bento-Bernardes T, Kindlovits R, Gomes TMB, Motta NAV, Brito FC, Fernandes-Santos C, Oliveira KJ, Nóbrega ACL. Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome. Br J Nutr. 2017 Jul;118(1):1-10. doi: 10.1017/S0007114517001702. Erratum in: Br J Nutr. 2017 Dec;118(11):998. PMID: 28799895.
5: Yen GC, Tsai LC, Lii JD. Antimutagenic effect of Maillard browning products obtained from amino acids and sugars. Food Chem Toxicol. 1992 Feb;30(2):127-32. doi: 10.1016/0278-6915(92)90147-d. PMID: 1555794.
6: Tarshis MA, Demikova NS, Migushina VL. Energetika aktivnogo transporta uglevodov v kletki mikoplazm [Energetics of active carbohydrate transport into mycoplasma cells]. Biokhimiia. 1978 Mar;43(3):498-503. Russian. PMID: 656486.
