Synonym
WZ-2; WZ2; WZ 2; Antifungal agent 96
IUPAC/Chemical Name
(Z)-8-(methoxyimino)-3-methylthieno[3',2':4,5]benzo[1,2-d]isoxazol-4(8H)-one
InChi Key
SHSJHJONOXSOOJ-JYRVWZFOSA-N
InChi Code
InChI=1S/C11H8N2O3S/c1-5-7-9(14)11-6(3-4-17-11)8(13-15-2)10(7)16-12-5/h3-4H,1-2H3/b13-8-
SMILES Code
O=C(C1=C/2ON=C1C)C3=C(C=CS3)C2=N\OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
248.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhong Y, Deng L, Shi S, Huang QY, Ou-Yang SM, Mo JS, Zhu K, Qu XM, Liu PQ,
Wang YX, Zhang XL. The novel STAT3 inhibitor WZ-2-033 causes regression of human
triple-negative breast cancer and gastric cancer xenografts. Acta Pharmacol Sin.
2022 Apr;43(4):1013-1023. doi: 10.1038/s41401-021-00718-0. Epub 2021 Jul 15.
PMID: 34267347; PMCID: PMC8976066.
2: Yang W, Liu R, Li Z, Tu J, Xu D, Liu N, Sheng C. Discovery of New Tricyclic
Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of
Cryptococcosis and Candidiasis. J Med Chem. 2024 Mar 28;67(6):4726-4738. doi:
10.1021/acs.jmedchem.3c02331. Epub 2024 Mar 15. PMID: 38489247.
3: Sun T, Miao J, Saleem M, Zhang H, Yang Y, Zhang Q. Bacterial compatibility
and immobilization with biochar improved tebuconazole degradation, soil
microbiome composition and functioning. J Hazard Mater. 2020 Nov 5;398:122941.
doi: 10.1016/j.jhazmat.2020.122941. Epub 2020 May 24. PMID: 32492617.
