GYZ-319 | NNMT inhibitor

MedKoo Cat#: 124439 | Name: GYZ-319

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GYZ-319 is a NNMT inhibitor

Chemical Structure

GYZ-319

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124439

Name: GYZ-319

CAS#: N/A

Chemical Formula: C24H28N8O5

Exact Mass: 508.2200

Molecular Weight: 508.54

Elemental Analysis: C, 56.68; H, 5.55; N, 22.03; O, 15.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GYZ-319; GYZ319; GYZ 319

IUPAC/Chemical Name

(S)-2-amino-4-((((2S,3R,4S,5S)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((E)-3-(4-cyanophenyl)allyl)amino)butanoic acid

InChi Key

DNXADBAIQDIPQK-CPFZLQAOSA-N

InChi Code

InChI=1S/C24H28N8O5/c25-10-15-5-3-14(4-6-15)2-1-8-31(9-7-16(26)24(35)36)11-17-19(33)20(34)23(37-17)32-13-30-18-21(27)28-12-29-22(18)32/h1-6,12-13,16-17,19-20,23,33-34H,7-9,11,26H2,(H,35,36)(H2,27,28,29)/b2-1+/t16?,17-,19-,20-,23-/m0/s1

SMILES Code

O[C@H]1[C@@H](O)[C@H](CN(C/C=C/C2=CC=C(C#N)C=C2)CC[C@H](N)C(O)=O)O[C@@H]1N3C=NC4=C(N)N=CN=C43

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 508.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

van Haren MJ, Gao Y, Buijs N, Campagna R, Sartini D, Emanuelli M, Mateuszuk L, Kij A, Chlopicki S, Escudé Martinez de Castilla P, Schiffelers R, Martin NI. Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity. Biomolecules. 2021 Sep 14;11(9):1357. doi: 10.3390/biom11091357. PMID: 34572571; PMCID: PMC8466754.