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MedKoo Cat#: 128193 | Name: BRP-201

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BRP-201 is a mPGES-1 inhibitor.

Chemical Structure

BRP-201
BRP-201
CAS#2227434-74-2

Theoretical Analysis

MedKoo Cat#: 128193

Name: BRP-201

CAS#: 2227434-74-2

Chemical Formula: C28H27ClN4OS

Exact Mass: 502.1594

Molecular Weight: 503.06

Elemental Analysis: C, 66.85; H, 5.41; Cl, 7.05; N, 11.14; O, 3.18; S, 6.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BRP-201; BRP201; BRP 201
IUPAC/Chemical Name
5-(1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thione
InChi Key
ZADYAZTTWZYTSD-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H27ClN4OS/c1-17(2)14-19-8-10-20(11-9-19)18(3)26-30-24-15-21(27-31-32-28(35)34-27)12-13-25(24)33(26)16-22-6-4-5-7-23(22)29/h4-13,15,17-18H,14,16H2,1-3H3,(H,32,35)
SMILES Code
S=C1OC(C2=CC=C3C(N=C(C(C4=CC=C(CC(C)C)C=C4)C)N3CC5=CC=CC=C5Cl)=C2)=NN1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 503.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ergül AG, Maz TG, Kretzer C, Olğaç A, Jordan PM, Çalışkan B, Werz O, Banoglu E. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. Eur J Med Chem. 2022 Mar 5;231:114167. doi: 10.1016/j.ejmech.2022.114167. Epub 2022 Feb 1. PMID: 35152061. 2: Kretzer C, Jordan PM, Bilancia R, Rossi A, Gür Maz T, Banoglu E, Schubert US, Werz O. Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro- Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201. J Inflamm Res. 2022 Feb 9;15:911-925. doi: 10.2147/JIR.S345510. PMID: 35173459; PMCID: PMC8842732. 3: Kretzer C, Shkodra B, Klemm P, Jordan PM, Schröder D, Cinar G, Vollrath A, Schubert S, Nischang I, Hoeppener S, Stumpf S, Banoglu E, Gladigau F, Bilancia R, Rossi A, Eggeling C, Neugebauer U, Schubert US, Werz O. Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood. Cell Mol Life Sci. 2021 Dec 31;79(1):40. doi: 10.1007/s00018-021-04039-7. PMID: 34971430; PMCID: PMC8966466. 4: Ismail J, Klepsch LC, Dahlke P, Tsarenko E, Vollrath A, Pretzel D, Jordan PM, Rezaei K, Czaplewska JA, Stumpf S, Beringer-Siemers B, Nischang I, Hoeppener S, Werz O, Schubert US. PEG-Lipid-PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs. Pharmaceutics. 2024 Jan 28;16(2):187. doi: 10.3390/pharmaceutics16020187. PMID: 38399248; PMCID: PMC10891717. 5: Tsarenko E, Göppert NE, Dahlke P, Behnke M, Gangapurwala G, Beringer-Siemers B, Jaepel L, Kellner C, Pretzel D, Czaplewska JA, Vollrath A, Jordan PM, Weber C, Werz O, Schubert US, Nischang I. Unveiling the power of liquid chromatography in examining a library of degradable poly(2-oxazoline)s in nanomedicine applications. J Mater Chem B. 2024 Nov 27;12(46):11926-11938. doi: 10.1039/d4tb01812e. PMID: 39434568.