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MedKoo Cat#: 526395 | Name: CT-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CT-1 is a novel orally active DNA minor groove ligand, against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis.

Chemical Structure

CT-1
CT-1
CAS#1983924-33-9

Theoretical Analysis

MedKoo Cat#: 526395

Name: CT-1

CAS#: 1983924-33-9

Chemical Formula: C29H23F3N4O

Exact Mass: 500.1824

Molecular Weight: 500.53

Elemental Analysis: C, 69.59; H, 4.63; F, 11.39; N, 11.19; O, 3.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CT-1; CT1; CT 1
IUPAC/Chemical Name
3,5-Bis-(2-fluoro-benzylidene)-1-[1-(4-fluoro-benzyl)-1H-[1,2,3]triazol-4-ylmethyl]-piperidin-4-one
InChi Key
GRSQHVJEBDBQLN-RNIAWFEPSA-N
InChi Code
InChI=1S/C29H23F3N4O/c30-25-11-9-20(10-12-25)15-36-19-26(33-34-36)18-35-16-23(13-21-5-1-3-7-27(21)31)29(37)24(17-35)14-22-6-2-4-8-28(22)32/h1-14,19H,15-18H2/b23-13+,24-14+
SMILES Code
O=C1/C(CN(CC2=CN(CC3=CC=C(F)C=C3)N=N2)C/C1=C\C4=CC=CC=C4F)=C/C5=CC=CC=C5F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 500.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Messerli M, Ottilinger T, Warschkow R, Leschka S, Alkadhi H, Wildermuth S, Bauer RW. Emphysema quantification and lung volumetry in chest X-ray equivalent ultralow dose CT - Intra-individual comparison with standard dose CT. Eur J Radiol. 2017 Jun;91:1-9. doi: 10.1016/j.ejrad.2017.03.003. Epub 2017 Mar 14. PubMed PMID: 28629554. 2: Jayaraman J, Choi S, Prokchorchik M, Choi DS, Spiandore A, Rikkerink EH, Templeton MD, Segonzac C, Sohn KH. A bacterial acetyltransferase triggers immunity in Arabidopsis thaliana independent of hypersensitive response. Sci Rep. 2017 Jun 15;7(1):3557. doi: 10.1038/s41598-017-03704-x. PubMed PMID: 28620210. 3: Rose-John S. Interleukin-6 Family Cytokines. Cold Spring Harb Perspect Biol. 2017 Jun 15. pii: a028415. doi: 10.1101/cshperspect.a028415. [Epub ahead of print] PubMed PMID: 28620096. 4: Taketomi S, Inui H, Tahara K, Shirakawa N, Tanaka S, Nakagawa T. Effects of initial graft tension on femoral tunnel widening after anatomic anterior cruciate ligament reconstruction using a bone-patellar tendon-bone graft. Arch Orthop Trauma Surg. 2017 Jun 14. doi: 10.1007/s00402-017-2728-5. [Epub ahead of print] PubMed PMID: 28616652. 5: Li Q, Yu Q, Na R, Liu B. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis. Braz J Med Biol Res. 2017 May 15;50(6):e5868. doi: 10.1590/1414-431X20175868. PubMed PMID: 28513772. 6: Afshar-Oromieh A, Wolf M, Haberkorn U, Kachelrieß M, Gnirs R, Kopka K, Schlemmer HP, Freitag MT. Effects of arm truncation on the appearance of the halo artifact in (68)Ga-PSMA-11 (HBED-CC) PET/MRI. Eur J Nucl Med Mol Imaging. 2017 May 15. doi: 10.1007/s00259-017-3718-0. [Epub ahead of print] PubMed PMID: 28508120. 7: Afshar-Oromieh A, Holland-Letz T, Giesel FL, Kratochwil C, Mier W, Haufe S, Debus N, Eder M, Eisenhut M, Schäfer M, Neels O, Hohenfellner M, Kopka K, Kauczor HU, Debus J, Haberkorn U. Diagnostic performance of (68)Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients. Eur J Nucl Med Mol Imaging. 2017 Aug;44(8):1258-1268. doi: 10.1007/s00259-017-3711-7. Epub 2017 May 12. PubMed PMID: 28497198. 8: Gutierrez NM, Newhouse JH. Maximum Arterial Contrast Concentrations With Computed Tomography and Left Ventriculography: Implications for Contrast Nephrotoxicity Risk. J Comput Assist Tomogr. 2017 May 6. doi: 10.1097/RCT.0000000000000624. [Epub ahead of print] PubMed PMID: 28481807. 9: Shellikeri S, Setser RM, Hwang TJ, Srinivasan A, Krishnamurthy G, Vatsky S, Girard E, Zhu X, Keller MS, Cahill AM. Real-time fluoroscopic needle guidance in the interventional radiology suite using navigational software for percutaneous bone biopsies in children. Pediatr Radiol. 2017 May 4. doi: 10.1007/s00247-017-3830-0. [Epub ahead of print] PubMed PMID: 28474255. 10: Heffernan MJ, Snyder B, Zhou H, Li X. Fluoroscopic imaging overestimates the screw tip to subchondral bone distance in a cadaveric model of slipped capital femoral epiphysis. J Child Orthop. 2017;11(1):36-41. doi: 10.1302/1863-2548-11-160174. PubMed PMID: 28439307; PubMed Central PMCID: PMC5382334. 11: Leonard A. Just a "Puff of Smoke". J La State Med Soc. 2017 Mar-Apr;169(2):48. Epub 2017 Apr 15. PubMed PMID: 28414666. 12: Chavali JS, Nelson R, Maurice MJ, Kara O, Mouracade P, Dagenais J, Reese J, Bayona P, Haber GP, Stein RJ. Hilar Parenchymal Oversew: a novel technique for robotic partial nephrectomy hilar tumor renorrhaphy. Int Braz J Urol. 2017 Apr 6;43. doi: 10.1590/S1677-5538.IBJU.2017.0049. [Epub ahead of print] PubMed PMID: 28379673. 13: Briana DD, Germanou Κ, Boutsikou Μ, Boutsikou T, Athanasopoulos Ν, Μarmarinos Α, Gourgiotis D, Malamitsi-Puchner Α. Potential prognostic biomarkers of cardiovascular disease in fetal macrosomia: the impact of gestational diabetes. J Matern Fetal Neonatal Med. 2017 Mar 15:1-6. doi: 10.1080/14767058.2017.1300651. [Epub ahead of print] PubMed PMID: 28298172. 14: Wang D, Liu X, Liu Y, Shen G, Zhu X, Li S. Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice. Exp Gerontol. 2017 Jun;92:42-45. doi: 10.1016/j.exger.2017.03.007. Epub 2017 Mar 8. PubMed PMID: 28285145. 15: Schmuck S, Nordlohne S, von Klot CA, Henkenberens C, Sohns JM, Christiansen H, Wester HJ, Ross TL, Bengel FM, Derlin T. Comparison of standard and delayed imaging to improve the detection rate of [(68)Ga]PSMA I&T PET/CT in patients with biochemical recurrence or prostate-specific antigen persistence after primary therapy for prostate cancer. Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):960-968. doi: 10.1007/s00259-017-3669-5. Epub 2017 Mar 9. PubMed PMID: 28280856. 16: Al Ahmed HA, Nada O. E2F3 transcription factor: A promising biomarker in lung cancer. Cancer Biomark. 2017;19(1):21-26. doi: 10.3233/CBM-160196. PubMed PMID: 28269748. 17: Kampe KK, Rotermund R, Tienken M, Thomalla G, Regier M, Klutmann S, Kluge S. Diagnostic Value of Positron Emission Tomography Combined with Computed Tomography for Evaluating Critically Ill Neurological Patients. Front Neurol. 2017 Feb 14;8:33. doi: 10.3389/fneur.2017.00033. eCollection 2017. PubMed PMID: 28261149; PubMed Central PMCID: PMC5306377. 18: Reisner A, Burns TG, Hall LB, Jain S, Weselman BC, De Grauw TJ, Ono KE, Blackwell LS, Chern JJ. Quality Improvement in Concussion Care: Influence of Guideline-Based Education. J Pediatr. 2017 May;184:26-31. doi: 10.1016/j.jpeds.2017.01.045. Epub 2017 Feb 21. PubMed PMID: 28233546. 19: Charvet L, Shaw M, Dobbs B, Frontario A, Sherman K, Bikson M, Datta A, Krupp L, Zeinapour E, Kasschau M. Remotely Supervised Transcranial Direct Current Stimulation Increases the Benefit of At-Home Cognitive Training in Multiple Sclerosis. Neuromodulation. 2017 Feb 22. doi: 10.1111/ner.12583. [Epub ahead of print] PubMed PMID: 28225155. 20: Zhao Y, Peng R, Zhao W, Liu Q, Guo Y, Zhao S, Xu D. Zhibitai and low-dose atorvastatin reduce blood lipids and inflammation in patients with coronary artery disease. Medicine (Baltimore). 2017 Feb;96(7):e6104. doi: 10.1097/MD.0000000000006104. PubMed PMID: 28207527; PubMed Central PMCID: PMC5319516.

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