MedKoo Cat#: 128127 | Name: LGD 6972 (ammonium salt)
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LGD-6972 is a glucagon receptor antagonist.

Chemical Structure

LGD 6972 (ammonium salt)
LGD 6972 (ammonium salt)
CAS#LGD 6972 (ammonium salt)

Theoretical Analysis

MedKoo Cat#: 128127

Name: LGD 6972 (ammonium salt)

CAS#: LGD 6972 (ammonium salt)

Chemical Formula: C43H49N3O5S

Exact Mass: 719.3393

Molecular Weight: 719.94

Elemental Analysis: C, 71.74; H, 6.86; N, 5.84; O, 11.11; S, 4.45

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 750.00 2 Weeks
10mg USD 1,050.00 2 Weeks
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Synonym
LGD 6972 (ammonium salt); LGD 6972; LGD-6972; LGD6972
IUPAC/Chemical Name
ammonium (R)-2-(4-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-4-yl)-3-oxo-3-((2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)amino)propyl)benzamido)ethane-1-sulfonate
InChi Key
VZJMFAKZCPXIGY-DRRLCDGFSA-N
InChi Code
InChI=1S/C43H46N2O5S.H3N/c1-28-25-29(2)40(30(3)26-28)35-17-21-38(22-18-35)45-42(47)39(27-31-7-9-36(10-8-31)41(46)44-23-24-51(48,49)50)34-13-11-32(12-14-34)33-15-19-37(20-16-33)43(4,5)6;/h7-22,25-26,39H,23-24,27H2,1-6H3,(H,44,46)(H,45,47)(H,48,49,50);1H3/t39-;/m1./s1
SMILES Code
CC1=C(C2=CC=C(C=C2)NC([C@@H](C3=CC=C(C4=CC=C(C=C4)C(C)(C)C)C=C3)CC5=CC=C(C=C5)C(NCCS(=O)([O-])=O)=O)=O)C(C)=CC(C)=C1.[NH4+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 719.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vajda EG, Logan D, Lasseter K, Armas D, Plotkin DJ, Pipkin JD, Li YX, Zhou R, Klein D, Wei X, Dilzer S, Zhi L, Marschke KB. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2017 Jan;19(1):24-32. doi: 10.1111/dom.12752. Epub 2016 Aug 31. PubMed PMID: 27501510; PubMed Central PMCID: PMC5215471.