Selenomethionine | amino acid containing selenium | 1464-42-2

MedKoo Cat#: 128121 | Name: Selenomethionine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Selenomethionine is a naturally occurring amino acid containing selenium and is a common natural food source.

Chemical Structure

Selenomethionine

CAS#1464-42-2

Theoretical Analysis

MedKoo Cat#: 128121

Name: Selenomethionine

CAS#: 1464-42-2

Chemical Formula: C5H11NO2Se

Exact Mass: 196.9955

Molecular Weight: 196.12

Elemental Analysis: C, 30.62; H, 5.65; N, 7.14; O, 16.32; Se, 40.27

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 450.00	2 Weeks
250mg	USD 850.00	2 Weeks

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Related CAS #

No Data

Synonym

Selenomethionine; Seleno-DL-methionine; DL-Selenomethionine

IUPAC/Chemical Name

2-amino-4-(methylselanyl)butanoic acid

InChi Key

RJFAYQIBOAGBLC-UHFFFAOYSA-N

InChi Code

InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)

SMILES Code

O=C(O)C(N)CC[Se]C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 196.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031. 6: Fan S, Lin L, Li P, Tian H, Shen J, Zhou L, Zhao Q, Zhang J, Qin Y, Tang C. Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice. Toxicology. 2024 Jan;501:153689. doi: 10.1016/j.tox.2023.153689. Epub 2023 Nov 30. PMID: 38040082. 7: Lei Y, Sun W, Xu T, Shan J, Gao M, Lin H. Selenomethionine modulates the JAK2 / STAT3 / A20 pathway through oxidative stress to alleviate LPS-induced pyroptosis and inflammation in chicken hearts. Biochim Biophys Acta Gen Subj. 2024 Apr;1868(4):130564. doi: 10.1016/j.bbagen.2024.130564. Epub 2024 Jan 23. PMID: 38272191. 8: Hussein RA, Ahmed M, Kuldyushev N, Schönherr R, Heinemann SH. Selenomethionine incorporation in proteins of individual mammalian cells determined with a genetically encoded fluorescent sensor. Free Radic Biol Med. 2022 Nov 1;192:191-199. doi: 10.1016/j.freeradbiomed.2022.09.019. Epub 2022 Sep 22. PMID: 36152916. 9: Zhang Z, Xu Y, Wang J, Xie H, Sun X, Zhu X, Wei L, Liu Y. Protective Effect of Selenomethionine on T-2 Toxin-Induced Rabbit Immunotoxicity. Biol Trace Elem Res. 2022 Jan;200(1):172-182. doi: 10.1007/s12011-021-02625-1. Epub 2021 Mar 8. PMID: 33682074. 10: Han Q, Liu H, Zhang R, Yang X, Bao J, Xing H. Selenomethionine protects against ammonia-induced apoptosis through inhibition of endoplasmic reticulum stress in pig kidneys. Ecotoxicol Environ Saf. 2021 Oct 15;223:112596. doi: 10.1016/j.ecoenv.2021.112596. Epub 2021 Aug 2. PMID: 34352572. 11: Hasuoka PE, Iglesias JP, Teves M, Kaplan MM, Ferrúa NH, Pacheco PH. Selenomethionine administration decreases the oxidative stress induced by post mortem ischemia in the heart, liver and kidneys of rats. Biometals. 2021 Aug;34(4):831-840. doi: 10.1007/s10534-021-00310-3. Epub 2021 Apr 28. PMID: 33913063. 12: Zheng Y, He T, Xie T, Wang J, Yang Z, Sun X, Wang W, Li S. Hydroxy- selenomethionine supplementation promotes the in vitro rumen fermentation of dairy cows by altering the relative abundance of rumen microorganisms. J Appl Microbiol. 2022 Apr;132(4):2583-2593. doi: 10.1111/jam.15392. Epub 2021 Dec 14. PMID: 34847280; PMCID: PMC9299881. 13: Ren Z, Ding T, He H, Wei Z, Shi R, Deng J. Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling. Front Immunol. 2022 Aug 18;13:952852. doi: 10.3389/fimmu.2022.952852. PMID: 36059492; PMCID: PMC9436478. 14: Zhuang C, Gao J, Liu G, Zhou M, Yang J, Wang D, Kastelic JP, Han B. Selenomethionine activates selenoprotein S, suppresses Fas/FasL and the mitochondrial pathway, and reduces Escherichia coli-induced apoptosis of bovine mammary epithelial cells. J Dairy Sci. 2021 Sep;104(9):10171-10182. doi: 10.3168/jds.2020-20034. Epub 2021 May 28. PMID: 34053755. 15: de Brito ANEF, Kaneko IN, Cavalcante DT, Cardoso AS, Fagundes NS, Fontinhas- Netto G, de Lima MR, da Silva JHV, Givisiez PEN, Costa FGP. Hydroxy- selenomethionine enhances the productivity and egg quality of 50- to 70-week-old semi-heavy laying hens under heat stress. Poult Sci. 2023 Feb;102(2):102320. doi: 10.1016/j.psj.2022.102320. Epub 2022 Nov 5. PMID: 36508950; PMCID: PMC9763846. 16: Patterson BH, Combs GF Jr, Taylor PR, Patterson KY, Moler JE, Wastney ME. Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine. Front Endocrinol (Lausanne). 2021 Mar 29;12:621687. doi: 10.3389/fendo.2021.621687. PMID: 33859616; PMCID: PMC8043082. 17: Smith JL, Thompson A. Reactivity of selenomethionine--dents in the magic bullet? Structure. 1998 Jul 15;6(7):815-9. doi: 10.1016/s0969-2126(98)00083-5. PMID: 9687376. 18: Schrauzer GN. The nutritional significance, metabolism and toxicology of selenomethionine. Adv Food Nutr Res. 2003;47:73-112. doi: 10.1016/s1043-4526(03)47002-2. PMID: 14639782. 19: Marshall JR, Burk RF, Payne Ondracek R, Hill KE, Perloff M, Davis W, Pili R, George S, Bergan R. Selenomethionine and methyl selenocysteine: multiple-dose pharmacokinetics in selenium-replete men. Oncotarget. 2017 Apr 18;8(16):26312-26322. doi: 10.18632/oncotarget.15460. PMID: 28412747; PMCID: PMC5432259. 20: Zhang Z, Sun Y, Xie H, Wang J, Zhang X, Shi Z, Liu Y. Protective effect of selenomethionine on kidney injury induced by ochratoxin A in rabbits. Environ Sci Pollut Res Int. 2023 Mar;30(11):29874-29887. doi: 10.1007/s11356-022-24297-7. Epub 2022 Nov 23. PMID: 36417076.