Synonym
Nifurpipone dihydrochloride; Nifurpipone 2HCl
IUPAC/Chemical Name
1-Piperazineacetic acid, 4-methyl-, ((5-nitro-2-furanyl)methylene)hydrazine, dihydrochloride
InChi Key
YMYRRKOVHNSFFF-PASYGRCESA-N
InChi Code
InChI=1S/C7H14N2O2.C5H5N3O3.2ClH/c1-8-2-4-9(5-3-8)6-7(10)11;6-7-3-4-1-2-5(11-4)8(9)10;;/h2-6H2,1H3,(H,10,11);1-3H,6H2;2*1H/b;7-3+;;
SMILES Code
N/N=C/C1=CC=C([N+]([O-])=O)O1.O=C(O)CN2CCN(C)CC2.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
386.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Veronese M, Salvaterra M, Barzaghi D, Setnikar I. Effects of different drugs on the urinary excretion of nifurpipone (NP) and of nitrofurantoin (NTF) in the rat. Arzneimittelforschung. 1975 Sep;25(9):1417-20. PubMed PMID: 1242665.
2: Setnikar I, Magistretti MJ. Toxicological studies on nifurpipone. Boll Chim Farm. 1975 Feb;114(2):73-84. PubMed PMID: 1203104.
3: Barzaghi D, Benvenuti C, Pariali A, Veronese M. [Various methods for determination of nifurpipone in the human urine]. Farmaco Prat. 1976 Jul;31(7):377-82. Italian. PubMed PMID: 821781.
4: Laudi M, Ferrando V, Fontana G, Sesia G. [Nifurpipone in inflammatory diseases of the urinary tract]. Minerva Urol. 1973 May-Jun;25(3):149-57. Italian. PubMed PMID: 4583091.
5: Fontani F, Setnikar I. [Example of chemico-physical characterization of new drug (nifurpipone)]. Farmaco Prat. 1973 Oct;28(10):547-58. Italian. PubMed PMID: 4769274.
6: Veronese M, Salvaterra M, Barzaghi D, Setnikar I. Urinary excretion in the rat of nifurpipone (NP) and of nitrofurantoin (NTF) administered by different routes. Arzneimittelforschung. 1974 Jan;24(1):39-43. PubMed PMID: 4206385.
7: Watts ME. Radiosensitization of hypoxic cells by a nitrofuran; dose-modifying and shoulder effects. Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Mar;31(3):237-50. PubMed PMID: 323170.
8: Fontani F, Massarani E, Nardi D, Tajana A. Determination of nifurpipone in urine. J Pharm Sci. 1972 Sep;61(9):1502-3. PubMed PMID: 5068967.
9: Barzaghi D, Benvenuti C, Buffa E, Marozzi E. [Urinary elimination of 4 diverse oral formulations of nifurpipone]. Farmaco Prat. 1977 Feb;32(2):92-8. Italian. PubMed PMID: 849778.
10: Veronese M, Setnikar I. [Nifurpipone disks for antibiograms]. Boll Chim Farm. 1975 Oct;114(10):577-81. Italian. PubMed PMID: 1220715.
11: Bompani R, Pesci M, Petronio G. [Nifurpipone in the chemotherapy of bacterial inflammation of the urinary ways in geriatrics]. Minerva Urol. 1975 Jan-Feb;27(1):12-23. Italian. PubMed PMID: 1196269.
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13: Fisher GJ, Watts ME, Patel KB, Adams GE. Sensitization of ultraviolet radiation damage in bacteria and mammalian cells. Br J Cancer Suppl. 1978 Jun;3:111-4. PubMed PMID: 354675; PubMed Central PMCID: PMC2149378.
14: Sheldon PW, Hill SA. Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice. Br J Cancer. 1977 Jun;35(6):795-808. PubMed PMID: 871367; PubMed Central PMCID: PMC2025527.
15: Michaels HB. Oxygen depletion in irradiated aqueous solutions containing electron affinic hypoxic cell radiosensitizers. Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1055-8. PubMed PMID: 3744926.
16: Denekamp J, Michael BD, Harris SR. Hypoxic cell radiosensitizers: comparative tests of some electron affinic compounds using epidermal cell survival in vivo. Radiat Res. 1974 Oct;60(1):119-32. PubMed PMID: 10881705.
