Synonym
Nifuroxime; CCRIS1180; CCRIS-1180; CCRIS 1180
IUPAC/Chemical Name
2-Furaldehyde, 5-nitro-, oxime, (Z)- (8CI)
InChi Key
PTBKFATYSVLSSD-UTCJRWHESA-N
InChi Code
InChI=1S/C5H4N2O4/c8-6-3-4-1-2-5(11-4)7(9)10/h1-3,8H/b6-3-
SMILES Code
O=[N+](C1=CC=C(/C=N\O)O1)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
156.09
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Aaronson CM. Generalized urticaria from sensitivity to nifuroxime. JAMA. 1969 Oct 20;210(3):557-8. PMID: 4241818.
2: HOSHIAI T, AKAO S, TAMURA S, ISHIBASHI Y, YAMAOKA K. [On the parasiticidal effects of furazolidone and nifuroxime on Trichomonas vaginalis]. Nihon Saikingaku Zasshi. 1962 Mar;17:196-9. Japanese. PMID: 14449156.
3: Sutherland RM, Durand RE. Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med. 1972 Dec;22(6):613-8. doi: 10.1080/09553007214551511. PMID: 4539385.
4: Wojtowicz PF, Diliberto JJ. Separation and quantitative assay of furazolidone and nifuroxime in suppositories by magnesium silicate adsorption column chromatography. J Pharm Sci. 1971 Sep;60(9):1385-6. doi: 10.1002/jps.2600600921. PMID: 4327888.
5: Lafleur MV, Loman H. Radiation damage to phi X174 DNA and biological effects. Radiat Environ Biophys. 1986;25(3):159-73. doi: 10.1007/BF01221222. PMID: 3025919.
6: Diab N, AbuZuhri A, Schuhmann W. Sequential-injection stripping analysis of nifuroxime using DNA-modified glassy carbon electrodes. Bioelectrochemistry. 2003 Oct;61(1-2):57-63. doi: 10.1016/s1567-5394(03)00060-4. PMID: 14642910.
7: Elsayed L, Hassan SM, Kelani KM, El-Fatatry HM. Simultaneous spectrophotometric determination of nifuroxime and furazolidone in pharmaceutical preparations. J Assoc Off Anal Chem. 1980 Sep;63(5):992-5. PMID: 6447688.
8: Blumenstiel K, Schöneck R, Yardley V, Croft SL, Krauth-Siegel RL. Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase. Biochem Pharmacol. 1999 Dec 1;58(11):1791-9. doi: 10.1016/s0006-2952(99)00264-6. PMID: 10571254.
9: Engel JJ, Vogt TR, Wilson DE. Cholestatic hepatitis after administration of furan derivatives. Arch Intern Med. 1975 May;135(5):733-5. PMID: 150825.
10: Tocher JH, Edwards DI. The interaction of nitroaromatic drugs with aminothiols. Biochem Pharmacol. 1995 Oct 26;50(9):1367-71. doi: 10.1016/0006-2952(95)02010-1. PMID: 7503785.
