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MedKoo Cat#: 128104 | Name: YK-2168

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YK-2168 is an CDK9 inhibitor. YK2168 exhibited improved CDK9 selectivity over AZD4573 and BAY1251152; also showed differentiated intravenous PK profile and remarkable solid tumor efficacy in a mouse gastric cancer SNU16 CDX model in preclinical studies.

Chemical Structure

YK-2168
YK-2168
CAS#2571068-74-9

Theoretical Analysis

MedKoo Cat#: 128104

Name: YK-2168

CAS#: 2571068-74-9

Chemical Formula: C16H18ClN5

Exact Mass: 315.1251

Molecular Weight: 315.81

Elemental Analysis: C, 60.85; H, 5.75; Cl, 11.23; N, 22.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
YK-2168; YK2168; YK 2168
IUPAC/Chemical Name
5-chloro-4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
InChi Key
HXJZLLNYPHBNSR-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H18ClN5/c1-22-9-11(7-20-22)15-12-6-14(10-2-4-18-5-3-10)21-16(12)19-8-13(15)17/h6-10,18H,2-5H2,1H3,(H,19,21)
SMILES Code
ClC1=CN=C(NC(C2CCNCC2)=C3)C3=C1C4=CN(C)N=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 315.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liu Y, Xu Z, Hu L, Xia L, Li Q, Zhou W, Chen Y, Li W, Jiang W, Zhu X, Gao X, Xia Y, Zhu Z, Chen S, Ding CZ. Discovery and preclinical profile of YK-2168, a differentiated selective CDK9 inhibitor in clinical development. Bioorg Med Chem Lett. 2024 Nov 1;112:129941. doi: 10.1016/j.bmcl.2024.129941. Epub 2024 Sep 1. PMID: 39222890.

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