E 5324 | CAS#141799-76-0 | acyl-CoA inhibitor

MedKoo Cat#: 584375 | Name: E 5324

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E 5324, an acyl-CoA cholesterol acyltransferase inhibitor, has been found to inhibit cholesterol esterification and CE mass in atherosclerotic foam cells, derived from either macrophages or arterial smooth muscle cells.

Chemical Structure

E 5324

CAS#141799-76-0

Theoretical Analysis

MedKoo Cat#: 584375

Name: E 5324

CAS#: 141799-76-0

Chemical Formula: C26H34N4O2

Exact Mass: 434.2682

Molecular Weight: 434.58

Elemental Analysis: C, 71.86; H, 7.89; N, 12.89; O, 7.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

E-5324; E5324; E 5324

IUPAC/Chemical Name

Urea, N-butyl-N'-(2-(3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy)-6-methylphenyl)-

InChi Key

NQZTZGNLFLQHKG-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H34N4O2/c1-4-6-16-27-26(31)29-24-20(3)12-10-15-23(24)32-18-11-17-30-19-28-25(22(30)5-2)21-13-8-7-9-14-21/h7-10,12-15,19H,4-6,11,16-18H2,1-3H3,(H2,27,29,31)

SMILES Code

O=C(NC1=C(C)C=CC=C1OCCCN2C(CC)=C(C3=CC=CC=C3)N=C2)NCCCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Azuma Y, Kawasaki T, Ohno K, Seto J, Yamada T, Yamasaki M, Nobuhara Y. Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. Jpn J Pharmacol. 1999 Feb;79(2):151-8. PubMed PMID: 10202850. 2: Kawasaki T, Miyazaki A, Hakamata H, Matsuda H, Horiuchi S. Biochemical evidence for oligomerization of rat adrenal acyl-coenzyme A:cholesterol acyltransferase. Biochem Biophys Res Commun. 1998 Mar 17;244(2):347-52. PubMed PMID: 9514926. 3: Kogushi M, Tanaka H, Ohtsuka I, Yamada T, Kobayashi H, Saeki T, Takada M, Hiyoshi H, Yanagimachi M, Kimura T, Yoshitake S, Saito I. Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA:cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits. Atherosclerosis. 1996 Aug 2;124(2):203-10. PubMed PMID: 8830933. 4: Nicholson AC, Pomerantz KB, Fujimori T, Hajjar DP. Inhibition of cholesterol esterification in macrophages and vascular smooth muscle foam cells: evaluation of E5324, an acyl-CoA cholesterol acyltransferase inhibitor. Lipids. 1995 Aug;30(8):771-4. PubMed PMID: 7475994. 5: Kogushi M, Tanaka H, Kobayashi H, Yamada T, Ohtsuka I, Kimura T, Saito I. Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages. Jpn J Pharmacol. 1995 Jun;68(2):191-9. PubMed PMID: 7563976. 6: Nagata Y, Yonemoto M, Iwasawa Y, Shimizu-Nagumo A, Hattori H, Sawazaki Y, Kamei T. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995 Mar 1;49(5):643-51. PubMed PMID: 7887979. 7: Tanaka H, Ohtsuka I, Kogushi M, Kimura T, Fujimori T, Saeki T, Hayashi K, Kobayashi H, Yamada T, Hiyoshi H, et al. Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis. 1994 Jun;107(2):187-201. PubMed PMID: 7980693.