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MedKoo Cat#: 128068 | Name: BTX6654

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations.

Chemical Structure

BTX6654
BTX6654
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128068

Name: BTX6654

CAS#: N/A

Chemical Formula: C50H57F4N9O5

Exact Mass: 939.4419

Molecular Weight: 940.06

Elemental Analysis: C, 63.88; H, 6.11; F, 8.08; N, 13.41; O, 8.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
BTX6654; BTX 6654; BTX-6654
IUPAC/Chemical Name
3-(6-fluoro-5-(1-(3-(4-(4-(1-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)phthalazin-6-yl)piperazine-1-carbonyl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChi Key
OZZGLWHPVOGDLB-LHMLQLIOSA-N
InChi Code
InChI=1S/C50H57F4N9O5/c1-29-36(5-4-6-41(29)50(52,53)54)30(2)55-46-40-26-35(7-8-37(40)31(3)57-58-46)60-21-23-62(24-22-60)48(67)33-13-19-61(20-14-33)45(65)15-18-59-16-11-32(12-17-59)38-25-34-28-63(49(68)39(34)27-42(38)51)43-9-10-44(64)56-47(43)66/h4-8,25-27,30,32-33,43H,9-24,28H2,1-3H3,(H,55,58)(H,56,64,66)/t30-,43?/m1/s1
SMILES Code
FC(F)(F)C1=C(C)C([C@@H](C)NC2=NN=C(C)C3=CC=C(N4CCN(C(C5CCN(C(CCN6CCC(C7=CC(CN(C8CCC(NC8=O)=O)C9=O)=C9C=C7F)CC6)=O)CC5)=O)CC4)C=C32)=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 940.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Begovich K, Schoolmeesters A, Rajapakse N, Martinez-Terroba E, Kumar M, Shakya A, Lai C, Greene S, Whitefield B, Okano A, Mali V, Huang S, Chourasia AH, Fung L. Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. Mol Cancer Ther. 2024 Apr 2;23(4):407-420. doi: 10.1158/1535-7163.MCT-23-0513. PMID: 38224565.