HIF-2α inhibitor 35r | HIF-2α inhibitor

MedKoo Cat#: 150053 | Name: HIF-2α inhibitor 35r

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HIF-2α inhibitor 35r displays the inhibition of VEGF-A secretion in cancer cells and prevention of Arg1 expression and activity in IL4-stimulated macrophages. HIF-2α inhibitor 35r also demonstrated gene modulation in vivo target.

Chemical Structure

HIF-2α inhibitor 35r

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 150053

Name: HIF-2α inhibitor 35r

CAS#: N/A

Chemical Formula: C12H13F5O4S2

Exact Mass: 380.0180

Molecular Weight: 380.34

Elemental Analysis: C, 37.90; H, 3.45; F, 24.98; O, 16.83; S, 16.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HIF-2α inhibitor 35r; 35r; 35 r; 35-r;

IUPAC/Chemical Name

(S)-5,5-Difluoro-3-(methylsulfonyl)-1-((S)-3,3,3-trifluoro-2-methylpropoxy)-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol

InChi Key

OBDBAEQKQSFFSR-XNCJUZBTSA-N

InChi Code

1S/C12H13F5O4S2/c1-5(12(15,16)17)4-21-9-6-3-11(13,14)8(18)7(6)10(22-9)23(2,19)20/h5,8,18H,3-4H2,1-2H3/t5-,8-/m0/s1

SMILES Code

O[C@@H]1C(F)(F)CC2=C(OC[C@H](C)C(F)(F)F)SC(S(=O)(C)=O)=C21

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 380.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Buchstaller HP, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, Dong L, Fuchß T, Germann M, Knehans T, Krier M, Lecomte M, Müller D, Müller SR, Leuthner B, Lindemann R, Musil D, Nowak M, Reither V, Rettig C, Schindler CEM, Pakulska U, Spuck D, Wegener A, Zarębski A. Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors. J Med Chem. 2023 Jul 13;66(13):8666-8686. doi: 10.1021/acs.jmedchem.3c00332. Epub 2023 Jul 5. PMID: 37403966.