PG-931 | peptide agonist of melanocortin receptor 4 | MC4R | CAS#667430-81-1

MedKoo Cat#: 127982 | Name: PG-931

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PG-931 is a peptide agonist of melanocortin receptor 4 (MC4R). It increases intracellular cAMP levels in CHO cells expressing MC4R with an EC50 value of 0.42 nM.

Chemical Structure

PG-931

CAS#667430-81-1

Theoretical Analysis

MedKoo Cat#: 127982

Name: PG-931

CAS#: 667430-81-1

Chemical Formula: C59H85N15O11

Exact Mass: 1179.6553

Molecular Weight: 1180.42

Elemental Analysis: C, 60.03; H, 7.26; N, 17.80; O, 14.91

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 650.00	2 Weeks
10mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

PG-931; PG931; PG 931

IUPAC/Chemical Name

(S)-1-((3R,6S,9S,12S,20S,25aS)-9-((1H-indol-3-yl)methyl)-20-((S)-2-acetamidohexanamido)-3-benzyl-6-(3-guanidinopropyl)-1,4,7,10,18,21-hexaoxotetracosahydro-1H-pyrrolo[2,1-l][1,4,7,10,13,18]hexaazacyclotricosine-12-carbonyl)-N-((S)-1-amino-3-methyl-1-oxobutan-2-yl)pyrrolidine-2-carboxamide

InChi Key

WOFDJLFPEWSAPJ-YEJBJNCVSA-N

InChi Code

InChI=1S/C59H85N15O11/c1-5-6-20-40(66-35(4)75)51(78)71-45-32-48(76)63-26-13-12-22-42(57(84)73-28-16-25-47(73)56(83)72-49(34(2)3)50(60)77)68-54(81)44(31-37-33-65-39-21-11-10-19-38(37)39)69-52(79)41(23-14-27-64-59(61)62)67-53(80)43(30-36-17-8-7-9-18-36)70-55(82)46-24-15-29-74(46)58(45)85/h7-11,17-19,21,33-34,40-47,49,65H,5-6,12-16,20,22-32H2,1-4H3,(H2,60,77)(H,63,76)(H,66,75)(H,67,80)(H,68,81)(H,69,79)(H,70,82)(H,71,78)(H,72,83)(H4,61,62,64)/t40-,41-,42-,43+,44-,45-,46-,47-,49-/m0/s1

SMILES Code

O=C(N[C@@H](CCCCNC(C[C@@H](C(N1[C@](CCC1)([H])C(N[C@@H](C(N[C@H](C(N2)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)C(N4[C@@H](CCC4)C(N[C@H](C(N)=O)C(C)C)=O)=O)[C@@H]2CC5=CNC6=CC=CC=C56

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,180.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E, Colombo G, Tomasi A, Catania A, Guarini S. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603. doi: 10.1038/sj.bjp.0707115. Epub 2007 Jan 22. PMID: 17245369; PMCID: PMC2189765. 2: Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res. 2003 Nov;62(5):199-206. doi: 10.1034/j.1399-3011.2003.00087.x. PMID: 14531843.