MedKoo Cat#: 208367 | Name: DW0254

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DW0254 is a small molecule capable of inhibiting RAC activation in acute lymphoblastic leukemia cell lines. It also demonstrates promising anti-leukemic activity in RAS-mutated cells.

Chemical Structure

DW0254
DW0254
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208367

Name: DW0254

CAS#: unknown

Chemical Formula: C25H28N4O2

Exact Mass: 416.2212

Molecular Weight: 416.53

Elemental Analysis: C, 72.09; H, 6.78; N, 13.45; O, 7.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DW-0254, D-W-0254
IUPAC/Chemical Name
3-(5-(2-(1H-Indol-3-yl)ethyl)-1,3,4-oxadiazol-2-yl)-N-(4-ethylbenzyl)-N-methylpropanamide
InChi Key
MYWFVOHKFIFWPL-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H28N4O2/c1-3-18-8-10-19(11-9-18)17-29(2)25(30)15-14-24-28-27-23(31-24)13-12-20-16-26-22-7-5-4-6-21(20)22/h4-11,16,26H,3,12-15,17H2,1-2H3
SMILES Code
O=C(N(CC1=CC=C(CC)C=C1)C)CCC2=NN=C(CCC3=CNC4=C3C=CC=C4)O2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 416.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Canovas Nunes S, De Vita S, Anighoro A, Autelitano F, Beaumont E, Klingbeil P, McGuinness M, Duvert B, Harris C, Yang L, Pokharel SP, Chen CW, Ermann M, Williams DA, Xu H. Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. Blood Cancer J. 2022 Apr 14;12(4):64. doi: 10.1038/s41408-022-00663-z. PMID: 35422065; PMCID: PMC9010429.