Ureidosuccinic acid is an intermediate in the de novo pyrimidine nucleotide biosynthesis pathway. It is formed from aspartate and carbamoyl phosphate via aspartate carbamoyltransferase. Ureidosuccinic acid (350 mg/kg) inhibits antitumor activity and toxicity induced by the aspartate carbamoyltransferase inhibitor N-phosphonacetyl-L-aspartate (PALA) in a murine Lewis lung carcinoma model.
MedKoo Cat#: 464824
Name: Ureidosuccinic Acid
CAS#: 923-37-5
Chemical Formula: C5H8N2O5
Exact Mass: 176.0400
Molecular Weight: 176.13
Elemental Analysis: C, 34.10; H, 4.58; N, 15.91; O, 45.42
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 1.0 | 2.85 | |
| DMSO | 1.0 | 2.85 | |
| PBS (pH 7.2) | 1.0 | 2.85 |
The following data is based on the product molecular weight 176.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
