NDI-101150 is a potent, selective, oral inhibitor of hematopoietic progenitor kinase 1 (HPK1), with a different immunotherapy mechanism to other checkpoint inhibitors. NDI-101150 demonstrated single-digit nanomolar HPK1 enzymatic IC50 potency with >300-fold selectivity against MAP4K family kinases. In vitro NDI-101150 treatment dose-dependently activated multiple primary human immune cells as evidenced by pro-inflammatory cytokine secretion in human CD8+ T-cells, increased IgG antibody secretion in CD19+ B-cells and enhanced antigen presentation capacity of CD11C+ dendritic cells (DCs). Similarly, HPK1 inhibition overcame adenosine and prostaglandin E2 tumor-mediated suppression of effector T-cells.
MedKoo Cat#: 127785
Name: NDI-101150
CAS#: 2628486-22-4
Chemical Formula: C27H27FN6O2
Exact Mass: 486.2180
Molecular Weight: 486.55
Elemental Analysis: C, 66.65; H, 5.59; F, 3.90; N, 17.27; O, 6.58
The following data is based on the product molecular weight 486.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
