RO0505376 is a α4β1 integrin antagonist. RO0505376 acts as an integrin α4β7 antagonist by mimicking the Ile/Leu-Asp motif. It binds to the integrin's metal ion-dependent adhesion site (MIDAS), stabilizing it in a closed conformation. This inhibits the receptor's ability to adopt the open state required for firm adhesion, thereby promoting rolling adhesion rather than stable interactions. This selective mechanism holds therapeutic potential for conditions involving leukocyte trafficking.
MedKoo Cat#: 123070
Name: RO0505376
CAS#: 343981-29-3
Chemical Formula: C24H19Cl2F3N2O4
Exact Mass: 526.0700
Molecular Weight: 527.32
Elemental Analysis: C, 54.67; H, 3.63; Cl, 13.45; F, 10.81; N, 5.31; O, 12.14
The following data is based on the product molecular weight 527.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
