DDO-3733 is a TPR-independent PP5 allosteric activator, which facilitates the dephosphorylation process of downstream substrates. Considering the negative regulatory effect of PP5 on heat shock transcription factor HSF1, pharmacologic activation of PP5 by DDO-3733 was found to reduce the HSP90 inhibitor-induced heat shock response.
MedKoo Cat#: 127651
Name: DDO-3733
CAS#: N/A
Chemical Formula: C10H6F2N2OS
Exact Mass: 240.0169
Molecular Weight: 240.23
Elemental Analysis: C, 50.00; H, 2.52; F, 15.82; N, 11.66; O, 6.66; S, 13.35
The following data is based on the product molecular weight 240.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
