XZ426 | CAS#1638504-52-5

MedKoo Cat#: 556352 | Name: XZ426

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity.

Chemical Structure

XZ426

CAS#1638504-52-5

Theoretical Analysis

MedKoo Cat#: 556352

Name: XZ426

CAS#: 1638504-52-5

Chemical Formula: C22H24F2N4O4

Exact Mass: 446.1766

Molecular Weight: 446.45

Elemental Analysis: C, 59.19; H, 5.42; F, 8.51; N, 12.55; O, 14.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

XZ426; XZ-426; XZ 426;

IUPAC/Chemical Name

1,8-Naphthyridine-3-carboxamide, 4-amino-N-[(2,4-difluorophenyl)methyl]-1,2-dihydro-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-

InChi Key

YZHRHLDMVJVVOL-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H24F2N4O4/c23-15-7-6-14(17(24)10-15)12-27-21(30)18-19(25)16-9-13(5-3-1-2-4-8-29)11-26-20(16)28(32)22(18)31/h6-7,9-11,29,32H,1-5,8,12,25H2,(H,27,30)

SMILES Code

O=C(C1=C(N)C2=CC(CCCCCCO)=CN=C2N(O)C1=O)NCC3=CC=C(F)C=C3F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

The HIV intasome is a large nucleoprotein assembly that mediates the integration of a DNA copy of the viral genome into host chromatin. Intasomes are targeted by the latest generation of antiretrovirals, integrase (IN) strand transfer inhibitors (INSTIs). Challenges associated with lentiviral intasome biochemistry have hindered high-resolution structural studies of how INSTIs bind to their native drug target.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Passos DO, Li M, Jóźwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke TR Jr, Craigie R, Lyumkis D. Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science. 2020 Feb 14;367(6479):810-814. doi: 10.1126/science.aay8015. Epub 2020 Jan 30. PMID: 32001521; PMCID: PMC7357238.