Synonym
PSB-CB5; PSBCB5; PSB CB5;
IUPAC/Chemical Name
(Z)-2-(3-((4-chlorobenzyl)oxy)benzylidene)-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
InChi Key
XJBQRMOGMULGPP-PDGQHHTCSA-N
InChi Code
1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12-
SMILES Code
ClC1=CC=C(COC2=CC=CC(\C=C3/N=C4SCCCN4C3=O)=C2)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
384.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fabisiak A, Fabisiak N, Mokrowiecka A, Malecka-Panas E, Jacenik D, Kordek R, Zielińska M, Kieć-Kononowicz K, Fichna J. Novel selective agonist of GPR18, PSB- KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain. Neurogastroenterol Motil. 2021 Mar;33(3):e14003. doi: 10.1111/nmo.14003. Epub 2020 Oct 14. PMID: 33058313.
2: Kotańska M, Mika K, Szafarz M, Kubacka M, Müller CE, Sapa J, Kieć-Kononowicz K. Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating. Pharmaceuticals (Basel). 2021 Mar 16;14(3):270. doi: 10.3390/ph14030270. PMID: 33809564; PMCID: PMC8002110.
3: Schoeder CT, Kaleta M, Mahardhika AB, Olejarz-Maciej A, Łażewska D, Kieć- Kononowicz K, Müller CE. Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18. Eur J Med Chem. 2018 Jul 15;155:381-397. doi: 10.1016/j.ejmech.2018.05.050. Epub 2018 Jun 1. PMID: 29902723.
