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MedKoo Cat#: 525464 | Name: LY 116467

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 116467 is a dopamine agonist. LY116467 increases serum corticosterone concentration in rats at a dose of 3 mg/kg.

Chemical Structure

LY 116467
LY 116467
CAS#57202-76-3

Theoretical Analysis

MedKoo Cat#: 525464

Name: LY 116467

CAS#: 57202-76-3

Chemical Formula: C17H22N2S

Exact Mass: 286.1504

Molecular Weight: 286.44

Elemental Analysis: C, 71.28; H, 7.74; N, 9.78; S, 11.19

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No Data
Synonym
LY 116467; LY-116467; LY116467.
IUPAC/Chemical Name
6-Methyl-8-((methylthio)methyl)ergoline (8beta)
InChi Key
HEZLHSNBFOCKCQ-YTXUZFAGSA-N
InChi Code
InChI=1S/C17H22N2S/c1-19-9-11(10-20-2)6-14-13-4-3-5-15-17(13)12(8-18-15)7-16(14)19/h3-5,8,11,14,16,18H,6-7,9-10H2,1-2H3/t11-,14?,16-/m1/s1
SMILES Code
[H][C@@]1(N(C)C[C@H](CSC)CC12)CC3=CNC4=CC=CC2=C43
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LY 116467 is a dopamine agonist.
In vitro activity:
TBD
In vivo activity:
LY116467, which contains an N-methyl substituent in place of the N-n-propyl substituent in pergolide, was less potent than pergolide in lowering brain levels of 3,4-dihydroxyphenylacetic acid (Dopac), the metabolite of dopamine. LY116467 increased serum corticosterone concentration in rats at a dose of 3 mg/kg (a higher dose than is required for pergolide), and the effect was prevented by spiperone pretreatment. Reference: Neuroendocrinology. 1983;36(4):285-90. https://pubmed.ncbi.nlm.nih.gov/6866215/

Preparing Stock Solutions

The following data is based on the product molecular weight 286.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Fuller RW, Snoddy HD, Mason NR, Clemens JA, Bemis KG. Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide. Neuroendocrinology. 1983;36(4):285-90. doi: 10.1159/000123469. PMID: 6866215.
In vitro protocol:
TBD
In vivo protocol:
Fuller RW, Snoddy HD, Mason NR, Clemens JA, Bemis KG. Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide. Neuroendocrinology. 1983;36(4):285-90. doi: 10.1159/000123469. PMID: 6866215.
1: Fuller RW, Snoddy HD, Mason NR, Clemens JA, Bemis KG. Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide. Neuroendocrinology. 1983;36(4):285-90. PubMed PMID: 6866215.

View History

ONO-2921

ONO-2921