TW-37 | CAS#877877-35-5 | Bcl-2 inhibitor

MedKoo Cat#: 205939 | Name: TW-37

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TW-37 is a small-molecule inhibitor of Bcl-2 family proteins, inhibited cell growth and induced apoptosis in pancreatic cancer. TW-37 induces cell growth inhibition and S-phase cell cycle arrest, with regulation of several important cell cycle-related genes like p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch-1, Jagged-1, and its downstream genes such as Hes-1 in vitro and in vivo.

Chemical Structure

TW-37

CAS#877877-35-5

Theoretical Analysis

MedKoo Cat#: 205939

Name: TW-37

CAS#: 877877-35-5

Chemical Formula: C33H35NO6S

Exact Mass: 573.2185

Molecular Weight: 573.70

Elemental Analysis: C, 69.09; H, 6.15; N, 2.44; O, 16.73; S, 5.59

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 400.00
10mg	USD 600.00
25mg	USD 950.00

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Related CAS #

No Data

Synonym

TW37; TW 37; TW-37.

IUPAC/Chemical Name

5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide

InChi Key

PQAPVTKIEGUPRN-UHFFFAOYSA-N

InChi Code

InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)

SMILES Code

O=C(NC1=CC=C(S(=O)(C2=CC=CC=C2C(C)(C)C)=O)C=C1)C3=CC(CC4=CC=CC=C4C(C)C)=C(O)C(O)=C3O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 573.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Guo C, Jiang X, Zhang Y, Bao G. Comprehensive analysis of tumor immune- related gene signature for predicting prognosis, immunotherapy, and drug sensitivity in bladder urothelial carcinoma. Transl Cancer Res. 2024 Dec 31;13(12):6732-6752. doi: 10.21037/tcr-24-1053. Epub 2024 Dec 24. PMID: 39816541; PMCID: PMC11730456. 2: Zhang X, Li J, Li X, Chen Z, Ren D, Zhang S. Adsorption properties and mechanisms of Cd by co-pyrolysis composite material derived from peanut biochar and tailing waste. Environ Geochem Health. 2025 Jan 3;47(2):37. doi: 10.1007/s10653-024-02352-1. PMID: 39751974. 3: Gao L, Liang E, Zhang D, Zhang Y, Zhang X, Jiang G, Chen S, Li N, Wang X, Shen Y. Epigenetic alternations and targeted therapy in intrauterine adhesion: A comparative study. Genomics. 2023 Sep;115(5):110673. doi: 10.1016/j.ygeno.2023.110673. Epub 2023 Jun 27. PMID: 37385390. 4: Cerna-Chavez R, Rozanska A, Poretti GL, Benvenisty N, Parulekar M, Lako M. Retinal pigment epithelium exhibits gene expression and phagocytic activity alterations when exposed to retinoblastoma chemotherapeutics. Exp Eye Res. 2023 Aug;233:109542. doi: 10.1016/j.exer.2023.109542. Epub 2023 Jun 17. PMID: 37331647. 5: Baig MMFA, Ma J, Gao X, Khan MA, Ali A, Farid A, Zia AW, Noreen S, Wu H. Exploring the robustness of DNA nanotubes framework for anticancer theranostics toward the 2D/3D clusters of hypopharyngeal respiratory tumor cells. Int J Biol Macromol. 2023 May 1;236:123988. doi: 10.1016/j.ijbiomac.2023.123988. Epub 2023 Mar 11. PMID: 36907299. 6: Melo G, Silva CAB, Hague A, Parkinson EK, Rivero ERC. Anticancer effects of putative and validated BH3-mimetic drugs in head and neck squamous cell carcinomas: An overview of current knowledge. Oral Oncol. 2022 Sep;132:105979. doi: 10.1016/j.oraloncology.2022.105979. Epub 2022 Jul 8. PMID: 35816876. 7: Zhang L, Ke W, Hu P, Li Z, Geng W, Guo Y, Song B, Jiang H, Zhang X, Wan C. N6-Methyladenosine-Related lncRNAs Are Novel Prognostic Markers and Predict the Immune Landscape in Acute Myeloid Leukemia. Front Genet. 2022 May 9;13:804614. doi: 10.3389/fgene.2022.804614. PMID: 35615374; PMCID: PMC9125310. 8: Rozanska A, Cerna-Chavez R, Queen R, Collin J, Zerti D, Dorgau B, Beh CS, Davey T, Coxhead J, Hussain R, Al-Aama J, Steel DH, Benvenisty N, Armstrong L, Parulekar M, Lako M. pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation. Stem Cells Transl Med. 2022 Apr 29;11(4):415-433. doi: 10.1093/stcltm/szac008. PMID: 35325233; PMCID: PMC9052432. 9: Castro MV, Barbero GA, Máscolo P, Ramos R, Quezada MJ, Lopez-Bergami P. ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation. Cell Mol Biol Lett. 2022 Mar 8;27(1):23. doi: 10.1186/s11658-022-00327-7. Erratum in: Cell Mol Biol Lett. 2022 Jul 3;27(1):54. doi: 10.1186/s11658-022-00357-1. PMID: 35260073; PMCID: PMC8903712. 10: Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV. KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 2021 May 4;33(5):1042-1061.e7. doi: 10.1016/j.cmet.2021.04.004. PMID: 33951465; PMCID: PMC8132466. 11: Yu R, Lu Y, Yu R, Xie J, Zhou S. Synergistic Effects of TW-37 and ABT-263 on Renal Cell Carcinoma Cells. Cancer Manag Res. 2021 Feb 3;13:953-963. doi: 10.2147/CMAR.S265788. PMID: 33568941; PMCID: PMC7868206. 12: Mori Y, Fink C, Ichimura T, Sako K, Mori M, Lee NN, Aschauer P, Padmanabha Das KM, Hong S, Song M, Padera RF, Weins A, Lee LP, Nasr ML, Dekaban GA, Dikeakos JD, Bonventre JV. KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. medRxiv [Preprint]. 2022 Jan 11:2020.09.16.20190694. doi: 10.1101/2020.09.16.20190694. PMID: 32995803; PMCID: PMC7523142. 13: Yang IH, Hong SH, Jung M, Ahn CH, Yoon HJ, Hong SD, Cho SD, Shin JA. Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling. Cancer Cell Int. 2020 Aug 26;20:405. doi: 10.1186/s12935-020-01495-2. PMID: 32863764; PMCID: PMC7448991. 14: Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B. Antitumor effect of TW-37, a BH3 mimetic in human oral cancer. Lab Anim Res. 2019 Dec 4;35:27. doi: 10.1186/s42826-019-0028-7. PMID: 32257914; PMCID: PMC7081630. 15: Yang LL, Wang HL, Yan YH, Liu S, Yu ZJ, Huang MY, Luo Y, Zheng X, Yu Y, Li GB. Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur J Med Chem. 2020 Apr 15;192:112201. doi: 10.1016/j.ejmech.2020.112201. Epub 2020 Mar 2. PMID: 32163813. 16: Wei H, Harper MT. Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets. Platelets. 2021 Jan 2;32(1):105-112. doi: 10.1080/09537104.2020.1724276. Epub 2020 Feb 21. PMID: 32079453. 17: Looney DP, Long ET, Potter AW, Xu X, Friedl KE, Hoyt RW, Chalmers CR, Buller MJ, Florian JP. Divers risk accelerated fatigue and core temperature rise during fully-immersed exercise in warmer water temperature extremes. Temperature (Austin). 2019 Apr 13;6(2):150-157. doi: 10.1080/23328940.2019.1599182. PMID: 31312674; PMCID: PMC6620004. 18: Yang IH, Ahn CH, Cho NP, Jin B, Lee W, Jung YC, Hong SD, Shin JA, Cho SD. Heme Oxygenase-1 is a Key Molecule Underlying Differential Response of TW-37-Induced Apoptosis in Human Mucoepidermoid Carcinoma Cells. Molecules. 2019 May 1;24(9):1700. doi: 10.3390/molecules24091700. PMID: 31052354; PMCID: PMC6539960. 19: Klenke S, Akdeli N, Stelmach P, Heukamp L, Schulte JH, Bachmann HS. The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines. BMC Cancer. 2019 Mar 18;19(1):243. doi: 10.1186/s12885-019-5439-1. PMID: 30885150; PMCID: PMC6423774. 20: Nakagata T, Yamada Y, Naito H. Energy expenditure, recovery oxygen consumption, and substrate oxidation during and after body weight resistance exercise with slow movement compared to treadmill walking. Physiol Int. 2018 Dec 1;105(4):371-385. doi: 10.1556/2060.105.2018.4.27. PMID: 30587026.