Ac-DEVD-CHO | CAS#169332-60-9 | Caspase-3 inhibitor

MedKoo Cat#: 463790 | Name: Ac-DEVD-CHO

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac-DEVD-CHO is a selective Caspase-3 inhibitor. Ac-DEVD-CHO scavenged approximately 20% of HO, but reduced caspase-3-like activities were detected in the presence of Ac-DEVD-CHO, supporting the involvement of Ac-DEVD-CHO in increasing microspore viability by reducing oxidative stress and caspase-3-like activity. Results indicate that Ac-DEVD-CHO protects cells from cell death by modulating caspase-like activity.

Chemical Structure

Ac-DEVD-CHO

CAS#169332-60-9

Theoretical Analysis

MedKoo Cat#: 463790

Name: Ac-DEVD-CHO

CAS#: 169332-60-9

Chemical Formula: C20H30N4O11

Exact Mass: 502.1911

Molecular Weight: 502.48

Elemental Analysis: C, 47.81; H, 6.02; N, 11.15; O, 35.02

Price and Availability

Size	Price	Availability
10mg	USD 750.00	2 Weeks
25mg	USD 1,450.00	2 Weeks
50mg	USD 2,650.00	2 Weeks
1g	USD 7,950.00	2 Weeks
2g	USD 12,950.00	2 Weeks

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Related CAS #

169332-60-9

Synonym

Ac-DEVD-CHO; AcDEVD-CHO; Ac DEVD-CHO; Ac-DEVDCHO; Ac-DEVD CHO; Ac DEVD CHO; AcDEVDCHO; Caspase-3 Inhibitor I; Caspase 3 Inhibitor I;

IUPAC/Chemical Name

(4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

InChi Key

UMBVAPCONCILTL-MRHIQRDNSA-N

InChi Code

InChI=1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1

SMILES Code

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C=O)=O)=O)[C@H](CC(O)=O)NC(C)=O

Appearance

Solid powder

Purity

>97% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 502.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sinha RK, Pospíšil P, Maheshwari P, Eudes F. Bcl-2△21 and Ac-DEVD-CHO Inhibit Death of Wheat Microspores. Front Plant Sci. 2016 Dec 26;7:1931. doi: 10.3389/fpls.2016.01931. PMID: 28082995; PMCID: PMC5184288. 2: Ran X, Yan Z, Yang Y, Hu G, Liu J, Hou S, Guo W, Kan X, Fu S. Dioscin Improves Pyroptosis in LPS-Induced Mice Mastitis by Activating AMPK/Nrf2 and Inhibiting the NF-κB Signaling Pathway. Oxid Med Cell Longev. 2020 Dec 30;2020:8845521. doi: 10.1155/2020/8845521. PMID: 33488936; PMCID: PMC7790561. 3: He M, Zhang G, Shen F, Li X. Effects of Z-VaD-Ala-Asp-Fluoromethyl Ketone (Z-VAD-FMK) and Acetyl-Asp-Glu-Val-Asp-Aldehyde(Ac-DEVD-CHO) on Inflammation and Mucus Secretion in Mice Exposed to Cigarette Smoke. Int J Chron Obstruct Pulmon Dis. 2023 Feb 5;18:69-78. doi: 10.2147/COPD.S385748. PMID: 36777242; PMCID: PMC9910210. 4: Lampert L, Timonen B, Smith S, Davidge B, Li H, Conley JF Jr, Singer JD, Jiao J. Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells. Chem Commun (Camb). 2014 Feb 7;50(10):1234-7. doi: 10.1039/c3cc48088g. PMID: 24336780; PMCID: PMC3929101. 5: Yao K, Wang K, Xu W, Sun Z, Shentu X, Qiu P. Caspase-3 and its inhibitor Ac- DEVD-CHO in rat lens epithelial cell apoptosis induced by hydrogen in vitro. Chin Med J (Engl). 2003 Jul;116(7):1034-8. PMID: 12890378. 6: Liu SZ, Mao JF, Wen D, Tan XP, Fu CY. [The treatment of retinal apoptosis by Caspase 3 inhibitor Ac-DEVD-CHO in experimental myopia]. Zhonghua Yan Ke Za Zhi. 2005 May;41(5):428-33. Chinese. PMID: 15938808. 7: Agniswamy J, Fang B, Weber IT. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65. doi: 10.1111/j.1742-4658.2007.05994.x. Epub 2007 Aug 14. PMID: 17697120. 8: Yoshimori A, Sakai J, Sunaga S, Kobayashi T, Takahashi S, Okita N, Takasawa R, Tanuma S. Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO. BMC Pharmacol. 2007 Jun 27;7:8. doi: 10.1186/1471-2210-7-8. PMID: 17594508; PMCID: PMC1931592. 9: Chen C, Jiang Z, Jiang Q, Dai W, Shao Q, Chen Q, Wang Y, Yang G. Caspase-3 and gasdermin E detection in peri-implantitis. Biochim Biophys Acta Mol Basis Dis. 2021 Nov 1;1867(11):166217. doi: 10.1016/j.bbadis.2021.166217. Epub 2021 Jul 14. PMID: 34273529. 10: Zhou T, Lin H, Jiang L, Yu T, Zeng C, Liu J, Yang Z. Mild hypothermia protects hippocampal neurons from oxygen-glucose deprivation injury through inhibiting caspase-3 activation. Cryobiology. 2018 Feb;80:55-61. doi: 10.1016/j.cryobiol.2017.12.004. Epub 2017 Dec 6. PMID: 29223591. 11: Vasilev D, Dubrovskaya NM, Nalivaeva NN. Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia. J Mol Neurosci. 2022 Jul;72(7):1516-1526. doi: 10.1007/s12031-022-01986-z. Epub 2022 Mar 28. PMID: 35344141. 12: Kang HJ, Lee YM, Bae KH, Kim SJ, Chung SJ. Structural asymmetry of procaspase-7 bound to a specific inhibitor. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1514-21. doi: 10.1107/S0907444913010196. Epub 2013 Jul 18. PMID: 23897474. 13: Tian X, Wang Y, Fan X, Shi Y, Zhang W, Hou Q, Liu R, Zhou G. Expression of Pork Plectin during Postmortem Aging. J Agric Food Chem. 2019 Oct 23;67(42):11718-11727. doi: 10.1021/acs.jafc.9b03040. Epub 2019 Oct 9. PMID: 31518118. 14: Dubrez L, Savoy I, Hamman A, Solary E. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. EMBO J. 1996 Oct 15;15(20):5504-12. PMID: 8896444; PMCID: PMC452295. 15: Ruetten H, Badorff C, Ihling C, Zeiher AM, Dimmeler S. Inhibition of caspase-3 improves contractile recovery of stunned myocardium, independent of apoptosis-inhibitory effects. J Am Coll Cardiol. 2001 Dec;38(7):2063-70. doi: 10.1016/s0735-1097(01)01670-9. PMID: 11738316. 16: Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J. Activation of caspase-2 in apoptosis. J Biol Chem. 1997 Aug 22;272(34):21010-7. doi: 10.1074/jbc.272.34.21010. PMID: 9261102. 17: Yoshizawa K, Kiuchi K, Nambu H, Yang J, Senzaki H, Kiyozuka Y, Shikata N, Tsubura A. Caspase-3 inhibitor transiently delays inherited retinal degeneration in C3H mice carrying the rd gene. Graefes Arch Clin Exp Ophthalmol. 2002 Mar;240(3):214-9. doi: 10.1007/s00417-002-0427-5. Epub 2002 Feb 19. PMID: 11935279. 18: Yayuan Y, Ling H, Qunli Y, Yongfang G, Hongmei S. Effects of caspase activity of yak meat and internal environment changing during aging. J Food Sci Technol. 2022 Apr;59(4):1362-1371. doi: 10.1007/s13197-021-05145-x. Epub 2021 Jun 3. PMID: 35250061; PMCID: PMC8882741. 19: Fang B, Boross PI, Tozser J, Weber IT. Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition. J Mol Biol. 2006 Jul 14;360(3):654-66. doi: 10.1016/j.jmb.2006.05.041. Epub 2006 Jun 2. PMID: 16781734. 20: Nakano H, Shinohara K. Time sequence analysis of caspase-3-independent programmed cell death and apoptosis in X-irradiated human leukemic MOLT-4 cells. Cell Tissue Res. 2002 Dec;310(3):305-11. doi: 10.1007/s00441-002-0635-7. Epub 2002 Oct 23. PMID: 12457229.