Synonym
1G244; 1G-244; 1G 244; PTX1210
IUPAC/Chemical Name
(S)-2-Amino-4-{4-[bis-(4-fluorophenyl)-methyl]piperazin-1-yl}-1-(1,3-dihydro-isoindol-2-yl)-butane-1,4-dione
InChi Key
ZKIQFLSGMMYCGS-SANMLTNESA-N
InChi Code
InChI=1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2/t26-/m0/s1
SMILES Code
O=C(N1CC2=C(C=CC=C2)C1)[C@@H](N)CC(N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
504.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Batista PSC, Menezes CB, Carvalho AJ, Portugal AF, Bastos EA, Cardoso MJ, Santos CV, Julio MPM. Performance of grain sorghum hybrids under drought stress using GGE biplot analyses. Genet Mol Res. 2017 Sep 21;16(3). doi: 10.4238/gmr16039761. PubMed PMID: 28973741.
2: Gabrilovac J, Čupić B, Zapletal E, Kraus O, Jakić-Razumović J. Dipeptidyl peptidase 9 (DPP9) in human skin cells. Immunobiology. 2017 Feb;222(2):327-342. doi: 10.1016/j.imbio.2016.09.007. Epub 2016 Sep 19. PubMed PMID: 27682012.
3: Han R, Wang X, Bachovchin W, Zukowska Z, Osborn JW. Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. Sci Rep. 2015 Aug 5;5:12348. doi: 10.1038/srep12348. PubMed PMID: 26242871; PubMed Central PMCID: PMC4525143.
4: Matheeussen V, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpé S, Augustyns K, De Meyer GR, De Meester I. Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis. Basic Res Cardiol. 2013 May;108(3):350. doi: 10.1007/s00395-013-0350-4. Epub 2013 Apr 23. PubMed PMID: 23608773.
5: Wu JJ, Tang HK, Yeh TK, Chen CM, Shy HS, Chu YR, Chien CH, Tsai TY, Huang YC, Huang YL, Huang CH, Tseng HY, Jiaang WT, Chao YS, Chen X. Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol. 2009 Jul 15;78(2):203-10. doi: 10.1016/j.bcp.2009.03.032. Epub 2009 Apr 11. PubMed PMID: 19439267.
