P2Y6R antagonist 50 | CAS# | P2Y6R antagonist

MedKoo Cat#: 130520 | Name: P2Y6R antagonist 50

Description:

WARNING: This product is for research use only, not for human or veterinary use.

P2Y6R antagonist 50 is a novel potent and selective P2Y6R antagonist (IC50 = 5.914 nM). It ameliorates DSS-induced ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation in colon tissues.

Chemical Structure

P2Y6R antagonist 50

CAS#P2Y6R antagonist 50

Theoretical Analysis

MedKoo Cat#: 130520

Name: P2Y6R antagonist 50

CAS#: P2Y6R antagonist 50

Chemical Formula: C18H17ClN4O

Exact Mass: 340.1091

Molecular Weight: 340.81

Elemental Analysis: C, 63.44; H, 5.03; Cl, 10.40; N, 16.44; O, 4.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

P2Y6R antagonist-50, P2Y6R-Ant-50, P2Y6R-Antag-50, P2Y6R-AA-50, P2Y6R-AN-50, P2Y6R-AT-50, P2Y6R Ant 50, P2Y6R Antag 50, P2Y6R AA 50, P2Y6R AN 50, P2Y6R AT 50

IUPAC/Chemical Name

2-(1-(tert-Butyl)-5-(furan-2-yl)-1H-pyrazol-3-yl)-5-chloro-1H-benzo[d]imidazole

InChi Key

MDMLYQRLSMYAKZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H17ClN4O/c1-18(2,3)23-15(16-5-4-8-24-16)10-14(22-23)17-20-12-7-6-11(19)9-13(12)21-17/h4-10H,1-3H3,(H,20,21)

SMILES Code

ClC1=CC=C2NC(C3=NN(C(C)(C)C)C(C4=CC=CO4)=C3)=NC2=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 340.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zhu Y, Zhou M, Cheng X, Wang H, Li Y, Guo Y, Wang Y, Tian S, Mao T, Zhang Z, Li D, Hu Q, Li H. Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy. J Med Chem. 2023 May 11;66(9):6315-6332. doi: 10.1021/acs.jmedchem.3c00210. Epub 2023 Apr 20. PMID: 37078976.