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MedKoo Cat#: 127539 | Name: Tamitinol dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tamitinol (also known as EMD 21657), a neurotropic drug that was developed as a cognition enhancer for the treatment of diffuse cerebral disease and organic brain syndrome.

Chemical Structure

Tamitinol dihydrochloride
Tamitinol dihydrochloride
CAS#59496-23-0 (2HCl)

Theoretical Analysis

MedKoo Cat#: 127539

Name: Tamitinol dihydrochloride

CAS#: 59496-23-0 (2HCl)

Chemical Formula: C11H20Cl2N2OS

Exact Mass: 298.0673

Molecular Weight: 299.25

Elemental Analysis: C, 44.15; H, 6.74; Cl, 23.69; N, 9.36; O, 5.35; S, 10.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
61711-37-3 (free base) 59496-23-0 (2HCl)
Synonym
Tamitinol dihydrochloride; Tamitinol; EMD 21657; EMD21657; EMD-21657
IUPAC/Chemical Name
4-((ethylamino)methyl)-2-methyl-5-((methylthio)methyl)pyridin-3-ol dihydrochloride
InChi Key
TYNOKGPWHONZDV-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H18N2OS.2ClH/c1-4-12-6-10-9(7-15-3)5-13-8(2)11(10)14;;/h5,12,14H,4,6-7H2,1-3H3;2*1H
SMILES Code
Cl.Cl.CCNCC1=C(O)C(C)=NC=C1CSC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 299.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Noël G, Jeanmart M, Reinhardt B. Treatment of the organic brain syndrome in the elderly. A double-blind comparison on the effects of a neurotropic drug and placebo. Neuropsychobiology. 1983;10(2-3):90-3. PubMed PMID: 6371575. 2: Lehmann E, Kretschmar JH, Brauer H, Reinhardt B. Interaction of changes in hospital environment and neurotropic co-medication in chronic psychiatric inpatient. A placebo controlled double-blind study. Pharmacopsychiatria. 1982 Mar;15(2):57-60. PubMed PMID: 7043497. 3: Sanz R, Bettschart W, Reinhardt B. Tamitinol in paedopsychiatric out-patient therapy. Pharmatherapeutica. 1981;3(1):40-5. PubMed PMID: 7323108. 4: Pöldinger W, Reinhardt B. Neurotropic drugs as co-medication to psychotropics. Combined administration of a neurotropic drug and a tetracyclic antidepressant. Int Pharmacopsychiatry. 1980;15(3):137-42. PubMed PMID: 7016800.

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