MedKoo Cat#: 208427 | Name: CY208-243 free base
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY208,243 was superior in improving the strength of neuronal outcome sensitivity to the working memory-related choice behavior in the T-maze.

Chemical Structure

CY208-243 free base
CY208-243 free base
CAS#100999-26-6 (free base)

Theoretical Analysis

MedKoo Cat#: 208427

Name: CY208-243 free base

CAS#: 100999-26-6 (free base)

Chemical Formula: C19H18N2

Exact Mass: 274.1470

Molecular Weight: 274.37

Elemental Analysis: C, 83.18; H, 6.61; N, 10.21

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
CY-208243; CY 208243; CY208243; CY-208-243; CY 208-243; CY208-243; Indolophenanthridine; CY208-243 free base;
IUPAC/Chemical Name
(2R,11R)-10-Methyl-10,15-diazapentacyclo[11.6.1.02,11.03,8.016,20]icosa-1(20),3,5,7,13,16,18-heptaene
InChi Key
WRNKIDLXXXIELU-IEBWSBKVSA-N
InChi Code
InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3/t17-,19-/m1/s1
SMILES Code
CN([C@]1([H])C2)CC3=CC=CC=C3[C@]1([H])C4=C5C2=CNC5=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 274.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang Y, Kocher SD, Lewis MM, Mailman RB. Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D1 Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms. Front Neurosci. 2022 Jun 16;16:898051. doi: 10.3389/fnins.2022.898051. PMID: 35784852; PMCID: PMC9244699. 2: Yoshioka Y, Sugino Y, Shibagaki F, Yamamuro A, Ishimaru Y, Maeda S. Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-κB p65 through the formation of dopamine quinone in microglia. Eur J Pharmacol. 2020 Jan 5;866:172826. doi: 10.1016/j.ejphar.2019.172826. Epub 2019 Nov 29. PMID: 31790652. 3: Yang Y, Lee SM, Imamura F, Gowda K, Amin S, Mailman RB. D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex. Mol Psychiatry. 2021 Feb;26(2):645-655. doi: 10.1038/s41380-018-0312-1. Epub 2018 Dec 7. PMID: 30532019; PMCID: PMC9710464. 4: Peppe A, Antal A, Tagliati M, Stanzione P, Bodis-Wollner I. D1 agonist CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. Neurosci Lett. 1998 Feb 27;243(1-3):5-8. doi: 10.1016/s0304-3940(98)00068-8. PMID: 9535099. 5: Isobe S. [The role of the dopaminergic system in the rat ovary]. Nihon Naibunpi Gakkai Zasshi. 1994 May 20;70(4):457-64. Japanese. doi: 10.1507/endocrine1927.70.4_457. PMID: 7958095. 6: Mori H, Arakawa S, Ohkawa T, Ohkawa R, Takada S, Morita T, Okinaga S. The involvement of dopamine in the regulation of steroidogenesis in rat ovarian cells. Horm Res. 1994;41 Suppl 1:36-40. doi: 10.1159/000183941. PMID: 7916316. 7: Dreher JK, Jackson DM. Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res. 1989 May 22;487(2):267-77. doi: 10.1016/0006-8993(89)90831-7. PMID: 2525062. 8: Jackson DM, Ross SB, Edwards SR. Dopamine D2 agonist-induced behavioural depression is reversed by dopamine D1 agonists. J Neural Transm. 1989;75(3):213-20. doi: 10.1007/BF01258632. PMID: 2784489. 9: Ross SB, Jackson DM, Wallis EM, Edwards SR. Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):512-8. doi: 10.1007/BF00182724. PMID: 3261844.