Synonym
CY 208-243; CY208-243; CY-208-243; Indolophenanthridine
IUPAC/Chemical Name
Benzeneacetic acid, alpha-hydroxy-, (R)-, compd. with (6aR-trans)-4,6,6a,7,8,12b-hexahydro-7-methylindolo[4,3-ab]phenanthridine (1:1)
InChi Key
CLKKRZVLYFLOET-UZFFZFNSSA-N
InChi Code
InChI=1S/C19H18N2.C8H8O3/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21;9-7(8(10)11)6-4-2-1-3-5-6/h2-8,10,17,19-20H,9,11H2,1H3;1-5,7,9H,(H,10,11)/t17-,19-;7-/m11/s1
SMILES Code
O=C(O)[C@H](O)C1=CC=CC=C1.CN(CC2=C([C@@]34[H])C=CC=C2)[C@]3([H])CC5=CNC6=C5C4=CC=C6
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
426.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang Y, Kocher SD, Lewis MM, Mailman RB. Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D1 Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms. Front Neurosci. 2022 Jun 16;16:898051. doi: 10.3389/fnins.2022.898051. PMID: 35784852; PMCID: PMC9244699.
2: Yoshioka Y, Sugino Y, Shibagaki F, Yamamuro A, Ishimaru Y, Maeda S. Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-κB p65 through the formation of dopamine quinone in microglia. Eur J Pharmacol. 2020 Jan 5;866:172826. doi: 10.1016/j.ejphar.2019.172826. Epub 2019 Nov 29. PMID: 31790652.
3: Yang Y, Lee SM, Imamura F, Gowda K, Amin S, Mailman RB. D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex. Mol Psychiatry. 2021 Feb;26(2):645-655. doi: 10.1038/s41380-018-0312-1. Epub 2018 Dec 7. PMID: 30532019; PMCID: PMC9710464.
4: Peppe A, Antal A, Tagliati M, Stanzione P, Bodis-Wollner I. D1 agonist CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. Neurosci Lett. 1998 Feb 27;243(1-3):5-8. doi: 10.1016/s0304-3940(98)00068-8. PMID: 9535099.
5: Isobe S. [The role of the dopaminergic system in the rat ovary]. Nihon Naibunpi Gakkai Zasshi. 1994 May 20;70(4):457-64. Japanese. doi: 10.1507/endocrine1927.70.4_457. PMID: 7958095.
6: Mori H, Arakawa S, Ohkawa T, Ohkawa R, Takada S, Morita T, Okinaga S. The involvement of dopamine in the regulation of steroidogenesis in rat ovarian cells. Horm Res. 1994;41 Suppl 1:36-40. doi: 10.1159/000183941. PMID: 7916316.
7: Dreher JK, Jackson DM. Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res. 1989 May 22;487(2):267-77. doi: 10.1016/0006-8993(89)90831-7. PMID: 2525062.
8: Jackson DM, Ross SB, Edwards SR. Dopamine D2 agonist-induced behavioural depression is reversed by dopamine D1 agonists. J Neural Transm. 1989;75(3):213-20. doi: 10.1007/BF01258632. PMID: 2784489.
9: Ross SB, Jackson DM, Wallis EM, Edwards SR. Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):512-8. doi: 10.1007/BF00182724. PMID: 3261844.
